Hybrid hydrogels based on keratin and alginate for tissue engineering

Silva R, Singh R, Sarker B, Papageorgiou DG, Juhasz JA, Roether J, Cicha I, Kaschta J, Schubert DW, Chrissafis K, Detsch R, Boccaccini AR (2014)

Publication Status: Published

Publication Type: Journal article, Original article

Publication year: 2014

Journal

Journal of Materials Chemistry B Royal Society of Chemistry

Book Volume: 2

Pages Range: 5441-5451

Journal Issue: 33

DOI: 10.1039/c4tb00776j

Abstract

Novel hybrid hydrogels based on alginate and keratin were successfully produced for the first time. The self-assembly properties of keratin, and its ability to mimic the extracellular matrix were combined with the excellent chemical and mechanical stability and biocompatibility of alginate to produce 2D and 3D hybrid hydrogels. These hybrid hydrogels were prepared using two different approaches: sonication, to obtain 2D hydrogels, and a pressure-driven extrusion technique to produce 3D hydrogels. All results indicated that the composition of the hydrogels had a significant effect on their physical properties, and that they can easily be tuned to obtain materials suitable for biological applications. The cell-material interaction was assessed through the use of human umbilical vein endothelial cells, and the results demonstrated that the alginate/keratin hybrid biomaterials supported cell attachment, spreading and proliferation. The results proved that such novel hybrid hydrogels might find applications as scaffolds for soft tissue regeneration. © 2014 the Partner Organisations.

Authors with CRIS profile

Raquel de Jesus Marques da Silva Lourenco Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Bapi Sarker Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Judith Roether Lehrstuhl für Werkstoffwissenschaften (Polymerwerkstoffe) Iwona Cicha Lehrstuhl für Innere Medizin II Joachim Kaschta Lehrstuhl für Werkstoffwissenschaften (Polymerwerkstoffe) Dirk Schubert Lehrstuhl für Werkstoffwissenschaften (Polymerwerkstoffe) Rainer Detsch Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

Aristotle University of Thessaloniki GR Greece (GR)

How to cite

APA:

Silva, R., Singh, R., Sarker, B., Papageorgiou, D.G., Juhasz, J.A., Roether, J.,... Boccaccini, A.R. (2014). Hybrid hydrogels based on keratin and alginate for tissue engineering. Journal of Materials Chemistry B, 2(33), 5441-5451. https://doi.org/10.1039/c4tb00776j

MLA:

Silva, Raquel, et al. "Hybrid hydrogels based on keratin and alginate for tissue engineering." Journal of Materials Chemistry B 2.33 (2014): 5441-5451.

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