Cycloaddition reactions of glycine imine anions to phenylazocarboxylic esters - A new access to 1,3,5-trisubstituted 1,2,4-triazoles

Lasch R, Heinrich M (2015)

Publication Status: Published

Publication Type: Journal article, Original article

Publication year: 2015

Journal

Tetrahedron

Publisher: Elsevier Ltd

Book Volume: 71

Pages Range: 4282-4295

Journal Issue: 25

DOI: 10.1016/j.tet.2015.04.078

Abstract

Phenylazocarboxylic tert-butyl esters have recently been shown to be highly versatile building blocks due to their ability to undergo nucleophilic aromatic substitutions under mild conditions, particularly well with [¹⁸F]fluoride, and to act as precursors for aryl radicals. In this article, we now report first examples for cycloaddition reactions to phenylazocarboxylates. In a one-pot reaction with readily accessible glycine imines, a variety of highly substituted 1,2,4-triazoles could be obtained.

Authors with CRIS profile

Roman Lasch Professur für Pharmazeutische Chemie Markus Heinrich Professur für Pharmazeutische Chemie

How to cite

APA:

Lasch, R., & Heinrich, M. (2015). Cycloaddition reactions of glycine imine anions to phenylazocarboxylic esters - A new access to 1,3,5-trisubstituted 1,2,4-triazoles. Tetrahedron, 71(25), 4282-4295. https://dx.doi.org/10.1016/j.tet.2015.04.078

MLA:

Lasch, Roman, and Markus Heinrich. "Cycloaddition reactions of glycine imine anions to phenylazocarboxylic esters - A new access to 1,3,5-trisubstituted 1,2,4-triazoles." Tetrahedron 71.25 (2015): 4282-4295.

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