How and why does the proteome respond to microgravity?

Beitrag in einer Fachzeitschrift

Details zur Publikation

Autor(en): Grimm D, Wise P, Lebert M, Richter P, Baatout S
Zeitschrift: Expert Review of Proteomics
Verlag: Expert Reviews (formerly Future Drugs)
Jahr der Veröffentlichung: 2011
Band: 8
Heftnummer: 1
Seitenbereich: 13-27
ISSN: 1478-9450


For medical and biotechnological reasons, it is important to study mammalian cells, animals, bacteria and plants exposed to simulated and real microgravity. It is necessary to detect the cellular changes that cause the medical problems often observed in astronauts, cosmonauts or animals returning from prolonged space missions. In order for in vitro tissue engineering under microgravity conditions to succeed, the features of the cell that change need to be known. In this article, we summarize current knowledge about the effects of microgravity on the proteome in different cell types. Many studies suggest that the effects of microgravity on major cell functions depend on the responding cell type. Here, we discuss and speculate how and why the proteome responds to microgravity, focusing on proteomic discoveries and their future potential.

FAU-Autoren / FAU-Herausgeber

Lebert, Michael PD Dr.
Lehrstuhl für Zellbiologie
Richter, Peter Dr.
Lehrstuhl für Zellbiologie

Autor(en) der externen Einrichtung(en)
Aarhus University
Belgian Nuclear Research Centre (SCK•CEN) / Studiecentrum voor Kernenergie / Centre d'Étude de l'énergie Nucléaire
University of California Los Angeles (UCLA)


Grimm, D., Wise, P., Lebert, M., Richter, P., & Baatout, S. (2011). How and why does the proteome respond to microgravity? Expert Review of Proteomics, 8(1), 13-27.

Grimm, Daniela, et al. "How and why does the proteome respond to microgravity?" Expert Review of Proteomics 8.1 (2011): 13-27.


Zuletzt aktualisiert 2018-10-08 um 10:54