How and why does the proteome respond to microgravity?

Journal article

Publication Details

Author(s): Grimm D, Wise P, Lebert M, Richter P, Baatout S
Journal: Expert Review of Proteomics
Publisher: Expert Reviews (formerly Future Drugs)
Publication year: 2011
Volume: 8
Journal issue: 1
Pages range: 13-27
ISSN: 1478-9450


For medical and biotechnological reasons, it is important to study mammalian cells, animals, bacteria and plants exposed to simulated and real microgravity. It is necessary to detect the cellular changes that cause the medical problems often observed in astronauts, cosmonauts or animals returning from prolonged space missions. In order for in vitro tissue engineering under microgravity conditions to succeed, the features of the cell that change need to be known. In this article, we summarize current knowledge about the effects of microgravity on the proteome in different cell types. Many studies suggest that the effects of microgravity on major cell functions depend on the responding cell type. Here, we discuss and speculate how and why the proteome responds to microgravity, focusing on proteomic discoveries and their future potential.

FAU Authors / FAU Editors

Lebert, Michael PD Dr.
Lehrstuhl für Zellbiologie
Richter, Peter Dr.
Lehrstuhl für Zellbiologie

External institutions
Aarhus University
Belgian Nuclear Research Centre (SCK•CEN) / Studiecentrum voor Kernenergie / Centre d'Étude de l'énergie Nucléaire
University of California Los Angeles (UCLA)

How to cite

Grimm, D., Wise, P., Lebert, M., Richter, P., & Baatout, S. (2011). How and why does the proteome respond to microgravity? Expert Review of Proteomics, 8(1), 13-27.

Grimm, Daniela, et al. "How and why does the proteome respond to microgravity?" Expert Review of Proteomics 8.1 (2011): 13-27.


Last updated on 2018-10-08 at 10:54