Cu-releasing bioactive glass/polycaprolactone coating on Mg with antibacterial and anticorrosive properties for bone tissue engineering

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autor(en): Yang Y, Zheng K, Liang Rf, Mainka A, Taccardi N, Roether J, Detsch R, Goldmann W, Virtanen S, Boccaccini AR
Zeitschrift: Biomedical Materials
Jahr der Veröffentlichung: 2017
Band: 13
Heftnummer: 1
ISSN: 1748-6041


Abstract


Copper (Cu)-containing bioactive glass nanoparticles (Cu-BGNs) were introduced in polycaprolactone (PCL) coating systems to improve the bioactivity, antibacterial property, and corrosion resistance of vulnerable magnesium matrices under physiological conditions. The influence of different amounts of Cu-BGNs in PCL coatings was thoroughly investigated determining the wettability, electrochemical properties, and antibacterial effects against Staphylococcus carnosus and Escherichia coli, as well as their cyto-compatibility. Cu-BGNs were observed randomly scattered in PCL coatings. Increasing concentration of Cu-BGNs resulted in slightly decreasing water contact angle, and reducing anti-corrosion properties of the Cu-BGNs composite coatings. Yet higher Cu-BGNs content in coatings led to more calcium phosphate formation on the surface after 7 days of immersion in DMEM, which was confirmed by FTIR and XPS. The growth of S. carnosus and E. coli was inhibited by Cu2+ ion released from Cu-BGN coatings. In addition, both direct and indirect cyto-compatibility experiments showed that the viability and proliferation of MG-63 cells on Cu-BGN coatings were highly increased compared to pure magnesium; however, an additional increase of Cu-BGNs concentration showed a slight decrease of cell proliferation and cell activity. In summary, Cu-BGN/PCL composite coatings impart magnesium-based biomaterials antibacterial and anticorrosive properties for clinical applications.



FAU-Autoren / FAU-Herausgeber

Boccaccini, Aldo R. Prof. Dr.-Ing.
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Detsch, Rainer Dr.-Ing.
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Goldmann, Wolfgang Prof.
Naturwissenschaftliche Fakultät
Liang, Rui fang
Professur für Molekulare und Experimentelle Chirurgie
Roether, Judith
Lehrstuhl für Werkstoffwissenschaften (Polymerwerkstoffe)
Taccardi, Nicola Dr.
Lehrstuhl für Chemische Reaktionstechnik
Virtanen, Sannakaisa Prof. Dr.
Professur für Werkstoffwissenschaften (Korrosion und Oberflächentechnik)
Yang, Yuyun
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Zheng, Kai Dr.-Ing.
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)


Zitierweisen

APA:
Yang, Y., Zheng, K., Liang, R.f., Mainka, A., Taccardi, N., Roether, J.,... Boccaccini, A.R. (2017). Cu-releasing bioactive glass/polycaprolactone coating on Mg with antibacterial and anticorrosive properties for bone tissue engineering. Biomedical Materials, 13(1). https://dx.doi.org/10.1088/1748-605X/aa87f2

MLA:
Yang, Yuyun, et al. "Cu-releasing bioactive glass/polycaprolactone coating on Mg with antibacterial and anticorrosive properties for bone tissue engineering." Biomedical Materials 13.1 (2017).

BibTeX: 

Zuletzt aktualisiert 2018-08-10 um 08:27