Coupled continuous chromatography and racemization processes for the production of pure enantiomers

Beitrag in einer Fachzeitschrift
(Originalarbeit)


Details zur Publikation

Autorinnen und Autoren: Swernath S, Kaspereit M, Kienle A
Zeitschrift: Chemical Engineering & Technology
Jahr der Veröffentlichung: 2014
Band: 37
Heftnummer: 4
Seitenbereich: 643-651
ISSN: 0930-7516
eISSN: 1521-4125
Sprache: Englisch


Abstract


Combining an enantioseparation by continuous chromatography with the racemization of the undesired enantiomer in a recycle is a promising approach. Two different cases were considered: limited conversion of the reaction with moderate product purity requirements and high conversion with high product purity requirements. For the first case, a simple plantwide control strategy is presented, manipulating the solvent removal in front of the racemization reactor. It is shown that the various disturbances can be compensated with this strategy without performing the more complex readjustment of the chromatographic unit. Further, it is shown that this strategy is likely to fail in the second scenario and that readjustment of the chromatographic unit is required for a successful control strategy. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.



FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Kaspereit, Malte Prof. Dr.-Ing.
Professur für Thermische Verfahrenstechnik


Zitierweisen

APA:
Swernath, S., Kaspereit, M., & Kienle, A. (2014). Coupled continuous chromatography and racemization processes for the production of pure enantiomers. Chemical Engineering & Technology, 37(4), 643-651. https://dx.doi.org/10.1002/ceat.201300597

MLA:
Swernath, Subramanian, Malte Kaspereit, and Achim Kienle. "Coupled continuous chromatography and racemization processes for the production of pure enantiomers." Chemical Engineering & Technology 37.4 (2014): 643-651.

BibTeX: 

Zuletzt aktualisiert 2019-26-06 um 10:08