Sialic Acid-Binding Immunoglobulin-like Lectin G Promotes Atherosclerosis and Liver Inflammation by Suppressing the Protective Functions of B-1 Cells
Gruber S, Hendrikx T, Tsiantoulas D, Ozsvar-Kozma M, Goederle L, Mallat Z, Witztum JL, Shiri-Sverdlov R, Nitschke L, Binder CJ (2016)
Publication Status: Published
Publication Type: Journal article
Publication year: 2016
Journal
Publisher: CELL PRESS
Book Volume: 14
Pages Range: 2348-2361
Journal Issue: 10
DOI: 10.1016/j.celrep.2016.02.027
Abstract
Atherosclerosis is initiated and sustained by hypercholesterolemia, which results in the generation of oxidized LDL (OxLDL) and other metabolic byproducts that trigger inflammation. Specific immune responses have been shown to modulate the inflammatory response during atherogenesis. The sialic acid-binding immunoglobulin-like lectin G (Siglec-G) is a negative regulator of the functions of several immune cells, including myeloid cells and B-1 cells. Here, we show that deficiency of Siglec-G in atherosclerosis-prone mice inhibits plaque formation and diet-induced hepatic inflammation. We further demonstrate that selective deficiency of Siglec-G in B cells alone is sufficient to mediate these effects. Levels of B-1 cell-derived natural IgM with specificity for OxLDL were significantly increased in the plasma and peritoneal cavity of Siglec-G-deficient mice. Consistent with the neutralizing functions of OxLDL-specific IgM, Siglec-G-deficient mice were protected from OxLDL-induced sterile inflammation. Thus, Siglec-G promotes atherosclerosis and hepatic inflammation by suppressing protective anti-inflammatory effector functions of B cells.
Authors with CRIS profile
Involved external institutions
Österreichische Akademie der Wissenschaften
Austria (AT)
University of Cambridge
United Kingdom (GB)
University of California, San Diego
United States (USA) (US)
Maastricht University
Netherlands (NL)
Austria (AT)
University of Cambridge
United Kingdom (GB)
University of California, San Diego
United States (USA) (US)
Maastricht University
Netherlands (NL)
How to cite
APA:
Gruber, S., Hendrikx, T., Tsiantoulas, D., Ozsvar-Kozma, M., Goederle, L., Mallat, Z.,... Binder, C.J. (2016). Sialic Acid-Binding Immunoglobulin-like Lectin G Promotes Atherosclerosis and Liver Inflammation by Suppressing the Protective Functions of B-1 Cells. Cell Reports, 14(10), 2348-2361. https://dx.doi.org/10.1016/j.celrep.2016.02.027
MLA:
Gruber, Sabrina, et al. "Sialic Acid-Binding Immunoglobulin-like Lectin G Promotes Atherosclerosis and Liver Inflammation by Suppressing the Protective Functions of B-1 Cells." Cell Reports 14.10 (2016): 2348-2361.
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