C-reactive protein and the acute phase reaction in geriatric patients

Beitrag in einer Fachzeitschrift

Details zur Publikation

Autorinnen und Autoren: Bertsch T, Triebel J, Bollheimer C, Christ M, Sieber C, Fassbender K, Heppner HJ
Zeitschrift: Zeitschrift für Gerontologie und Geriatrie
Jahr der Veröffentlichung: 2015
Band: 48
Heftnummer: 7
Seitenbereich: 595-600
ISSN: 0948-6704


The C-reactive protein (CRP), first described as a serum component capable of precipitating the C-polysaccharide of pneumococci, is one of the most important proteins because the serum concentration rises in the acute phase reaction. The acute phase reaction is the nonspecific reaction of the body to noxious stimuli of the most varied kinds, such as infections, burns, neoplasms and tissue trauma. The CRP is synthesized in liver parenchymal cells by cytokines which are derived from stimulated leucocytes and released into the circulation. Because of its molecular structure and in synergy with the complement system, it is able to precipitate and/or lyse microorganisms, thereby rendering them harmless. Measurement of the serum CRP concentration can provide important information with respect to the diagnosis and monitoring of treatment. Due to immunosenescence in geriatric patients the synthesis of CRP appears to be limited to inflammatory stimuli; however, this phenomenon does not appear to be of major clinical relevance. Despite the introduction of new parameters of the acute phase reaction, sometimes with better performance, such as interleukin-6, procalcitonin and the soluble endotoxin receptor sCD14, measurement of CRP for diagnosis and treatment monitoring is still justified even in geriatric patients as testing is rapid, economic and nearly ubiquitously available round the clock. Biochemical markers of the acute phase reaction should always be interpreted together with the clinical picture and their specific limitations.

FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Sieber, Cornel Prof. Dr.
Lehrstuhl für Innere Medizin (Geriatrie)

Einrichtungen weiterer Autorinnen und Autoren

Krankenhaus Barmherzige Brüder, Academic Teaching Hospital of University Medical Center Regensburg
Paracelsus Medizinische Privatuniversität
Private Universität Witten/Herdecke gGmbH
Universitätsklinikum des Saarlandes


Bertsch, T., Triebel, J., Bollheimer, C., Christ, M., Sieber, C., Fassbender, K., & Heppner, H.J. (2015). C-reactive protein and the acute phase reaction in geriatric patients. Zeitschrift für Gerontologie und Geriatrie, 48(7), 595-600. https://dx.doi.org/10.1007/s00391-015-0938-4

Bertsch, Thomas, et al. "C-reactive protein and the acute phase reaction in geriatric patients." Zeitschrift für Gerontologie und Geriatrie 48.7 (2015): 595-600.


Zuletzt aktualisiert 2018-08-10 um 08:22