Structural characterization of intracellular C-terminal domains of group III metabotropic glutamate receptors.

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autorinnen und Autoren: Seebahn A, Dinkel H, Mohrlüder J, Hartmann R, Vogel N, Becker CM, Sticht H, Enz R
Zeitschrift: Febs Letters
Verlag: Elsevier
Jahr der Veröffentlichung: 2011
Heftnummer: 585
Seitenbereich: 511-516
ISSN: 0014-5793


Abstract

Metabotropic glutamate receptors (mGluRs) are regulated by interacting proteins that mostly bind to their intracellular C-termini. Here, we investigated if mGluR6, mGluR7a and mGluR8a C-termini form predefined binding surfaces or if they were rather unstructured. Limited tryptic digest of purified peptides argued against the formation of stable globular folds. Circular dichroism,
1H NMR and
1H
15N HSQC spectra indicated the absence of rigid secondary structure elements. Furthermore, we localized short linear binding motifs in the unstructured receptor domains. Our data provide evidence that protein interactions of the analyzed mGluR C-termini are mediated rather by short linear motifs than by preformed folds. © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.


FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Becker, Cord-Michael Prof. Dr.
Lehrstuhl für Biochemie und Molekulare Medizin
Enz, Ralf Prof. Dr.
Professur für Biochemie und Medizinische Molekularbiologie
Hartmann, Rainer
Professur für Informatik (Numerische Simulation mit Höchstleistungsrechnern)
Sticht, Heinrich Prof. Dr.
Professur für Bioinformatik


Einrichtungen weiterer Autorinnen und Autoren

European Molecular Biology Laboratory (EMBL)


Zitierweisen

APA:
Seebahn, A., Dinkel, H., Mohrlüder, J., Hartmann, R., Vogel, N., Becker, C.-M.,... Enz, R. (2011). Structural characterization of intracellular C-terminal domains of group III metabotropic glutamate receptors. Febs Letters, 585, 511-516. https://dx.doi.org/10.1016/j.febslet.2010.12.042

MLA:
Seebahn, Angela, et al. "Structural characterization of intracellular C-terminal domains of group III metabotropic glutamate receptors." Febs Letters 585 (2011): 511-516.

BibTeX: 

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