Regulation of the anaphase-promoting complex by the COP9 signalosome

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Details zur Publikation

Autorinnen und Autoren: Kob R, Kelm J, Posorski N, Baniahmad A, Von Eggeling F, Melle C
Zeitschrift: Cell Cycle
Verlag: Landes Bioscience
Jahr der Veröffentlichung: 2009
Band: 8
Heftnummer: 13
Seitenbereich: 2041-2049
ISSN: 1538-4101


The COP9 complex (signalosome) is a known regulator of the proteasome/ubiquitin pathway. Furthermore it regulates the activity of the cullin-RING ligase (CRL) families of ubiquitin E3-complexes. Besides the CRL family, the anaphase-promoting complex (APC/C) is a major regulator of the cell cycle. To investigate a possible connection between both complexes we assessed interacting partners of COP9 using an in vivo protein-protein interaction assay. Hereby, we were able to show for the first time that CSN2, a subunit of the COP9 signalosome, interacts physically with APC/C. Furthermore, we detected a functional influence of the COP9 complex regarding the stability of several targets of the APC/C. Consistent with these data we showed a genetic instability of cells overexpressing CSN2.

FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Kob, Robert Dr.
Professur für Innere Medizin - Geriatrie

Einrichtungen weiterer Autorinnen und Autoren

Universitätsklinikum Jena


Kob, R., Kelm, J., Posorski, N., Baniahmad, A., Von Eggeling, F., & Melle, C. (2009). Regulation of the anaphase-promoting complex by the COP9 signalosome. Cell Cycle, 8(13), 2041-2049.

Kob, Robert, et al. "Regulation of the anaphase-promoting complex by the COP9 signalosome." Cell Cycle 8.13 (2009): 2041-2049.


Zuletzt aktualisiert 2018-08-08 um 18:54