Balasubramanian P, Roether J, Schubert DW, Beier J, Boccaccini AR (2015)
Publication Status: Published
Publication Type: Journal article, Original article
Publication year: 2015
Publisher: Springer Verlag (Germany)
Book Volume: 22
Pages Range: 1215-1226
Journal Issue: 5
DOI: 10.1007/s10934-015-9998-5
A simple yet promising approach to construct bi-layered scaffolds using bioactive ceramics and biodegradable polymers is presented. This method involves two versatile fabrication techniques used in the field of TE: foam replication process and electrospinning. By the foam replication method, three-dimensional 45S5 bioactive glass (BG)-based scaffolds with high porosity, in the range of 95.8 ± 0.9 %, were produced. To improve the mechanical properties of the BG scaffolds, dip-coating using polycaprolactone (PCL) was performed, which led to a significant increase in the compressive strength of the scaffolds. In order to develop a bi-layered construct, bead-less submicrometric fibers of collagen-PCL were electrospun over the PCL-coated BG scaffolds. Surface morphology, surface properties and mechanical strength of the bi-layered construct were evaluated using scanning electron microscopy analysis, contact angle measurements and compressive strength testing, respectively. In vitro degradation of the collagen-PCL fibers in phosphate buffered saline and in vitro bioactivity of the bi-layered constructs in simulated body fluid were investigated. Formation of hydroxyapatite on the PCL-coated BG and along the morphology of the collagen-PCL fibers was ascertained using different characterization techniques. The bi-layered construct is intended for interface tissue engineering applications where the PCL-coated BG scaffold, which is highly bioactive, can serve as a support for the bone side and the composite collagen-PCL submicrometric fibers are intended for the cartilage side.
APA:
Balasubramanian, P., Roether, J., Schubert, D.W., Beier, J., & Boccaccini, A.R. (2015). Bi-layered porous constructs of PCL-coated 45S5 bioactive glass and electrospun collagen-PCL fibers. Journal of Porous Materials, 22(5), 1215-1226. https://dx.doi.org/10.1007/s10934-015-9998-5
MLA:
Balasubramanian, Preethi, et al. "Bi-layered porous constructs of PCL-coated 45S5 bioactive glass and electrospun collagen-PCL fibers." Journal of Porous Materials 22.5 (2015): 1215-1226.
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