Wegner M (2008)
Publication Type: Journal article, Original article
Publication year: 2008
Publisher: Elsevier
Pages Range: 217-226
Journal Issue: 8
DOI: 10.1016/j.gep.2008.01.001
NEDD9 is a scaffolding protein in the integrin signaling pathway that is involved in cell adhesion dynamics. Little is known of the cellular localization of NEDD9 expression during embryonic development. In the present study, we have analyzed NEDD9 mRNA expression in the mouse and identified new relevant expression sites. In addition, we have characterized NEDD9 protein expression pattern for the first time in mammals. At E9.5-E10.5, high levels of Nedd9 and the neurogenic transcription factor neurogenin-2 (Ngn2) were found to largely overlap in two discrete domains of the trunk neural tube along its dorso-ventral axis, with Nedd9 extending to more ventral regions of the ventricular zone and Ngn2 differentially expressed in neuronally committed progenitors of the intermediate zone. At encephalic and trunk levels of the neural tube, NEDD9 was present in Sox2+ progenitor cell populations mostly generating Ngn2+ and/or Nurr1+ cells. A sharp down-regulation of NEDD9 expression was found in cells upon lineage commitment, as observed in Nurr1+ and Ngn2+ mesencephalic dopaminergic and brainstem neuronal progenitors. In other tissues/organs, i.e. prospective heart, retina, olfactory epithelium, gonads, cartilage, gut and pituitary gland, NEDD9 was found to be co-expressed with Sox2, RXR alpha and/or Nurr1-like proteins, suggesting that NEDD9 expression is confined to early progenitors involved in diverse organogenesis and that it may depend on the repertoire and levels of retinoic acid co-receptors expressed by those cells. © 2008 Elsevier B.V. All rights reserved.
APA:
Wegner, M. (2008). Differential expression and dynamic changes of murine NEDD9 in progenitor cells of diverse tissues. Gene Expression Patterns, 8, 217-226. https://dx.doi.org/10.1016/j.gep.2008.01.001
MLA:
Wegner, Michael. "Differential expression and dynamic changes of murine NEDD9 in progenitor cells of diverse tissues." Gene Expression Patterns 8 (2008): 217-226.
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