Vascularisation for cardiac tissue engineering: the extracellular matrix

Patra C, Boccaccini AR, Engel F (2015)


Publication Status: Published

Publication Type: Journal article

Publication year: 2015

Journal

Publisher: Schattauer

Book Volume: 113

Pages Range: 532-547

Journal Issue: 3

DOI: 10.1160/TH14-05-0480

Abstract

Cardiovascular diseases present a major socio-economic burden. One major problem underlying most cardiovascular and congenital heart diseases is the irreversible loss of contractile heart muscle cells, the cardiomyocytes. To reverse damage incurred by myocardial infarction or by surgical correction of cardiac malformations, the loss of cardiac tissue with a thickness of a few millimetres needs to be compensated. A promising approach to this issue is cardiac tissue engineering. In this review we focus on the problem of in vitro vascularisation as implantation of cardiac patches consisting of more than three layers of cardiomyocytes (>100 mu m thick) already results in necrosis. We explain the need for vascularisation and elaborate on the importance to include non-myocytes in order to generate functional vascularised cardiac tissue. We discuss the potential of extracellular matrix molecules in promoting vascularisation and introduce nephronectin as an, example of a new promising candidate. Finally, we discuss current biomaterial-based approaches including micropatterning, electrospinning, 3D micro-manufacturing technology and porogens. Collectively, the current literature supports the notion that cardiac tissue engineering is a realistic option for future treatment of paediatric and adult patients with cardiac disease.

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How to cite

APA:

Patra, C., Boccaccini, A.R., & Engel, F. (2015). Vascularisation for cardiac tissue engineering: the extracellular matrix. Thrombosis and Haemostasis, 113(3), 532-547. https://dx.doi.org/10.1160/TH14-05-0480

MLA:

Patra, Chinmoy, Aldo R. Boccaccini, and Felix Engel. "Vascularisation for cardiac tissue engineering: the extracellular matrix." Thrombosis and Haemostasis 113.3 (2015): 532-547.

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