Depolarisation of the plasma membrane in the arsenic trioxide (As2O3)-and anti-CD95-induced apoptosis in myeloid cells.

Nolte F, Friedrich O, ROjewski M, Fink R, Schrezenmeier H, Körper S (2004)

Publication Status: Published

Publication Type: Journal article

Publication year: 2004

Journal

Febs Letters Elsevier

Publisher: Elsevier

Book Volume: 578

Pages Range: 85-9

Journal Issue: 1-2

DOI: 10.1016/j.febslet.2004.10.075

Abstract

Depolarisation of the plasma membrane has been shown to be actively regulated during lymphocyte-apoptosis. Here, we present data about anti-Fas and As2O3 induced depolarisation of myeloid U-937 cells. Anti-Fas but not As2O3-induced depolarisation was significantly dependent on caspase-activation. Na+-fluxes contributed to the depolarisation in early stages of As2O3-induced apoptosis, whereas the membrane potential in late stages depended on Cl- -fluxes. Cl- -channels also played an important role in the induction of cell shrinkage in As2O3-induced apoptosis. However, none of these ions contributed significantly to anti-Fas induced depolarisation. This indicates the existence of different mechanisms for apoptotic plasma membrane depolarisation within one cell type.

Authors with CRIS profile

Oliver Friedrich Lehrstuhl für Medizinische Biotechnologie

Involved external institutions

Ruprecht-Karls-Universität Heidelberg DE Germany (DE) Universität Ulm DE Germany (DE) Hochschule Ulm DE Germany (DE)

How to cite

APA:

Nolte, F., Friedrich, O., ROjewski, M., Fink, R., Schrezenmeier, H., & Körper, S. (2004). Depolarisation of the plasma membrane in the arsenic trioxide (As2O3)-and anti-CD95-induced apoptosis in myeloid cells. Febs Letters, 578(1-2), 85-9. https://doi.org/10.1016/j.febslet.2004.10.075

MLA:

Nolte, Florian, et al. "Depolarisation of the plasma membrane in the arsenic trioxide (As2O3)-and anti-CD95-induced apoptosis in myeloid cells." Febs Letters 578.1-2 (2004): 85-9.

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