Development and characterization of lithium-releasing silicate bioactive glasses and their scaffolds for bone repair

Miguez Pacheco V, Büttner T, Macon ALB, Jones JR, Fey T, de Ligny D, Greil P, Chevalier J, Malchere A, Boccaccini AR (2016)

Publication Language: English

Publication Status: Published

Publication Type: Journal article, Original article

Publication year: 2016

Journal

Publisher: Elsevier

Book Volume: 432

Pages Range: 65-72

Journal Issue: Part A

DOI: 10.1016/j.jnoncrysol.2015.03.027

Abstract

Incorporation of therapeutic ions into the structure of bioactive glasses for direct stimulation of cells is a very attractive approach for tissue engineering strategies. Lithium has recently been identified as a biologically active ion which can stimulate osteoblast cell activity. In this study, lithium-containing bioactive glasses (Li-BGs) where Li2O substitutes Na2O in different amounts (2.5, 5 and 10 wt.% Li2O) in 45S5 bioactive glass (BC) were produced and made into 3D scaffolds by the foam replica method. The structural changes that occur after heat treatment, the effect of lithium-content on the bioactivity of the glasses and their lithium ion release profiles were investigated. The results show that the novel Li-BC formulations exhibit the formation of an apatite-like layer on their surface after immersion in SBF for 1 day thus confirming their high surface reactivity, similar to undoped 45S5 BC. XRD results showed that the Li-doped BGs crystallize mainly to combeite (Na2Ca2Si3O9) and silicorhenanite (SiO4(PO4)(2)Ca-5) but also Li6P6O18 and Li3PO4 phases were detected. In terms of lithium ion release, the formulations at 2.5 wt.% and 5 wt.% Li2O content were the only ones to be within the therapeutic range (<83 ppm). (C) 2015 Elsevier B.V. All rights reserved.

Authors with CRIS profile

Involved external institutions

Imperial College London / The Imperial College of Science, Technology and Medicine United Kingdom (GB) MATEIS France (FR)

How to cite

APA:

Miguez Pacheco, V., Büttner, T., Macon, A.L.B., Jones, J.R., Fey, T., de Ligny, D.,... Boccaccini, A.R. (2016). Development and characterization of lithium-releasing silicate bioactive glasses and their scaffolds for bone repair. Journal of Non-Crystalline Solids, 432(Part A), 65-72. https://doi.org/10.1016/j.jnoncrysol.2015.03.027

MLA:

Miguez Pacheco, Valentina, et al. "Development and characterization of lithium-releasing silicate bioactive glasses and their scaffolds for bone repair." Journal of Non-Crystalline Solids 432.Part A (2016): 65-72.

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