Chitosan membranes containing micro or nano-size bioactive glass particles: evolution of biomineralization followed by in situ dynamic mechanical analysis

Caridade SG, Merino EG, Alves NM, Bermudez VDZ, Boccaccini AR, Mano JF (2013)

Publication Type: Journal article

Publication year: 2013

Journal

Journal of the Mechanical Behavior of Biomedical Materials Elsevier

Publisher: Elsevier

Book Volume: 20

Pages Range: 173-183

DOI: 10.1016/j.jmbbm.2012.11.012

Abstract

A new family of biodegradable polymer/bioactive glass (BG) composite materials has emerged based on the availability of nano-sized bioactive particles. Such novel biocomposites can have enhanced performance, in terms of mechanical properties and bioactivity, and they can be designed to be used in bone regeneration approaches.In this work, membranes of chitosan (CTS) and chitosan with bioactive glass (BG) both micron and nano sized particles (CTS/μBG, CTS/nBG, respectively) were prepared by solvent casting. Microstructural and mechanical properties were evaluated in order to compare the effects of the incorporation of micro (μBG) and nano (nBG) particles in the chitosan matrix. In vitro bioactivity tests were performed to characterize the apatite layer that is formed on the surface of the material after being immersed in simulated body fluid (SBF). The biomineralization process on the biomaterials was also followed using non-conventional dynamic mechanical analysis (DMA), both online and offline. In such DMA experiments, the change in the storage modulus, E', and the loss factor, tan δ, were measured as a function of the immersion time in SBF. The results demonstrated that CTS/nBG membranes possess enhanced mechanical properties and higher bioactivity in comparison with the CTS/μBG membranes. Such results suggest the potential of nBG for the development of bioactive composites for bone regeneration applications. © 2012 Elsevier Ltd.

Authors with CRIS profile

Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

Universidade de Trás-os-Montes e Alto Douro (UTAD) PT Portugal (PT) Universidade do Minho PT Portugal (PT)

How to cite

APA:

Caridade, S.G., Merino, E.G., Alves, N.M., Bermudez, V.D.Z., Boccaccini, A.R., & Mano, J.F. (2013). Chitosan membranes containing micro or nano-size bioactive glass particles: evolution of biomineralization followed by in situ dynamic mechanical analysis. Journal of the Mechanical Behavior of Biomedical Materials, 20, 173-183. https://doi.org/10.1016/j.jmbbm.2012.11.012

MLA:

Caridade, Sofia G., et al. "Chitosan membranes containing micro or nano-size bioactive glass particles: evolution of biomineralization followed by in situ dynamic mechanical analysis." Journal of the Mechanical Behavior of Biomedical Materials 20 (2013): 173-183.

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