Stratified scaffolds for osteochondral tissue engineering applications: Electrospun PDLLA nanofibre coated Bioglass®-derived foams

Yunos DM, Ahmad Z, Salih V, Boccaccini AR (2013)

Publication Type: Journal article

Publication year: 2013

Journal

Journal of Biomaterials Applications SAGE Publications

Publisher: SAGE Publications (UK and US)

Book Volume: 27

Pages Range: 537-551

Journal Issue: 5

DOI: 10.1177/0885328211414941

Abstract

This work focuses on designing bilayered constructs by combining electrospun poly-DL-Lactide (PDLLA) fibers and Bioglass®-derived scaffolds for development of osteochondral tissue replacement materials. Electrospinning was carried out using a solution of 5 wt/v% PDLLA in dimethyl carbonate. The PDLLA layer thickness increased from 2 to 150 μm with varying electrospinning time. Bioactivity studies in simulated body fluid showed that HA mineralization decreased as the thickness of the PDLLA layer increased. A preliminary in vitro study using chondrocyte cells (ATDC5) showed that cells attached, proliferated and migrated into the fibrous network, confirming the potential applicability of the bilayered scaffolds in osteochondral defect regeneration. © The Author(s) 2011 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

Authors with CRIS profile

Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

University of Portsmouth GB United Kingdom (GB) Imperial College London / The Imperial College of Science, Technology and Medicine GB United Kingdom (GB) University College London (UCL) GB United Kingdom (GB)

How to cite

APA:

Yunos, D.M., Ahmad, Z., Salih, V., & Boccaccini, A.R. (2013). Stratified scaffolds for osteochondral tissue engineering applications: Electrospun PDLLA nanofibre coated Bioglass®-derived foams. Journal of Biomaterials Applications, 27(5), 537-551. https://doi.org/10.1177/0885328211414941

MLA:

Yunos, D. M., et al. "Stratified scaffolds for osteochondral tissue engineering applications: Electrospun PDLLA nanofibre coated Bioglass®-derived foams." Journal of Biomaterials Applications 27.5 (2013): 537-551.

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