The transcription factors Sox10 and Myrf define an essential regulatory network module in differentiating oligodendrocytes

Hornig J, Fröb F, Vogl M, Hermans-Borgmeyer I, Tamm ER, Wegner M (2013)

Publication Type: Journal article

Publication year: 2013

Journal

PLoS Genetics Public Library of Science

Publisher: Public Library of Science

Book Volume: 9

Pages Range: e1003907

Journal Issue: 10

DOI: 10.1371/journal.pgen.1003907

Abstract

Myelin is essential for rapid saltatory conduction and is produced by Schwann cells in the peripheral nervous system and oligodendrocytes in the central nervous system. In both cell types the transcription factor Sox10 is an essential component of the myelin-specific regulatory network. Here we identify Myrf as an oligodendrocyte-specific target of Sox10 and map a Sox10 responsive enhancer to an evolutionarily conserved element in intron 1 of the Myrf gene. Once induced, Myrf cooperates with Sox10 to implement the myelination program as evident from the physical interaction between both proteins and the synergistic activation of several myelin-specific genes. This is strongly reminiscent of the situation in Schwann cells where Sox10 first induces and then cooperates with Krox20 during myelination. Our analyses indicate that the regulatory network for myelination in oligodendrocytes is organized along similar general principles as the one in Schwann cells, but is differentially implemented.

Authors with CRIS profile

Julia Hornig Lehrstuhl für Biochemie und Pathobiochemie Franziska Thiele Lehrstuhl für Biochemie und Pathobiochemie Michael Vogl Lehrstuhl für Biochemie und Pathobiochemie Michael Wegner Lehrstuhl für Biochemie und Pathobiochemie

Additional Organisation(s)

Emil-Fischer-Zentrum (Emil Fischer Center)

Involved external institutions

Universitätsklinikum Hamburg-Eppendorf (UKE) DE Germany (DE) Universität Regensburg DE Germany (DE)

How to cite

APA:

Hornig, J., Fröb, F., Vogl, M., Hermans-Borgmeyer, I., Tamm, E.R., & Wegner, M. (2013). The transcription factors Sox10 and Myrf define an essential regulatory network module in differentiating oligodendrocytes. PLoS Genetics, 9(10), e1003907. https://dx.doi.org/10.1371/journal.pgen.1003907

MLA:

Hornig, Julia, et al. "The transcription factors Sox10 and Myrf define an essential regulatory network module in differentiating oligodendrocytes." PLoS Genetics 9.10 (2013): e1003907.

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