Rietveld structure and in vitro analysis on the influence of Magnesium in Biphasic (Hydroxyapatite and beta-Tricalcium phosphate) mixtures

Kannan S, Götz-Neunhoeffer F, Neubauer J, Rebelo A, Valério P, da Fonte Ferreira JM (2009)

Publication Language: English

Publication Type: Journal article

Publication year: 2009

Journal

Journal of Biomedical Materials Research Part B-Applied Biomaterials Wiley-Blackwell

Publisher: Wiley-Blackwell

Book Volume: 90

Pages Range: 404-411

DOI: 10.1002/jbm.b.31299

Abstract

The structure of two different Mg-substituted biphasic (HAP and β-TCP) mixtures along with the biphasic mixtures without substituted Mg2+ was investigated using Rietveld refinement technique. The substituted Mg 2+ was found in the β-TCP phase and its influence on the composition has led to an increase in HAP content of Mg-containing biphasic mixtures when compared with the HAP content detected in pure biphasic mixtures. The refined structural parameters of Ca10(PO4) 6(OH)2 and β-Ca3(PO4) 2 confirmed that all the investigated compositions have crystallized in the corresponding hexagonal (space group P63/m) and rhombohedral (space group R3c) structures. The substitution of lower sized magnesium was found preferentially incorporated at the sixfold-coordinated Ca (5) site of β-TCP, which is due to the strong Ca (5)·O interaction among all the five different Ca sites of β-Ca3(PO4)2. The in vitro tests using primary culture of osteoblasts showed that all the tested samples are biocompatible and promising materials for in vivo studies. © 2008 Wiley Periodicals, Inc.

Authors with CRIS profile

Friedlinde Götz-Neunhoeffer Lehrstuhl für Mineralogie Jürgen Neubauer Lehrstuhl für Mineralogie

Involved external institutions

University of Aveiro / Universidade de Aveiro PT Portugal (PT) Pondicherry University IN India (IN) Universidade Federal de Minas Gerais (UFMG) BR Brazil (BR)

How to cite

APA:

Kannan, S., Götz-Neunhoeffer, F., Neubauer, J., Rebelo, A., Valério, P., & da Fonte Ferreira, J.M. (2009). Rietveld structure and in vitro analysis on the influence of Magnesium in Biphasic (Hydroxyapatite and beta-Tricalcium phosphate) mixtures. Journal of Biomedical Materials Research Part B-Applied Biomaterials, 90, 404-411. https://doi.org/10.1002/jbm.b.31299

MLA:

Kannan, Sanjeevi, et al. "Rietveld structure and in vitro analysis on the influence of Magnesium in Biphasic (Hydroxyapatite and beta-Tricalcium phosphate) mixtures." Journal of Biomedical Materials Research Part B-Applied Biomaterials 90 (2009): 404-411.

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