Reproducibility of Kidney Perfusion Measurements With Arterial Spin Labeling at 1.5 Tesla MRI Combined With Semiautomatic Segmentation for Differential Cortical and Medullary Assessment

Hammon M, Janka RM, Siegl C, Seuß H, Grosso R, Martirosian P, Schmieder R, Uder M, Kistner I (2016)

Publication Type: Journal article

Publication year: 2016

Journal

Medicine Lippincott, Williams & Wilkins

Book Volume: 95

Pages Range: e3083

Journal Issue: 11

DOI: 10.1097/MD.0000000000003083

Abstract

Magnetic resonance imaging with arterial spin labeling (ASL) is a noninvasive approach to measure organ perfusion. The purpose of this study was to evaluate the reproducibility of ASL kidney perfusion measurements with semiautomatic segmentation, which allows separate quantification of cortical and medullary perfusion.The right kidneys of 14 healthy volunteers were examined 6 times on 2 occasions (3 times at each occasion). There was a 10-minute pause between each examination and a 14-day interval between the 2 occasions. Cortical, medullary, and whole kidney parenchymal perfusion was determined with customized semiautomatic segmentation software. Coefficient of variances (CVs) and intraclass correlations (ICCs) were calculated.Mean whole, cortical, and medullary kidney perfusion was 307.26 ± 25.65, 337.10 ± 34.83, and 279.61 ± 26.73 mL/min/100 g, respectively. On session 1, mean perfusion for the whole kidney, cortex, and medulla was 307.08 ± 26.91, 336.79 ± 36.54, and 279.60 ± 27.81 mL/min/100 g, respectively, and on session 2, 307.45 ± 24.65, 337.41 ± 33.48, and 279.61 ± 25.94 mL/min/100 g, respectively (P > 0.05; R = 0.60/0.59/0.54). For whole, cortical, and medullary kidney perfusion, the total ICC/CV were 0.97/3.43 ± 0.86%, 0.97/4.19 ± 1.33%, and 0.96/4.12 ± 1.36%, respectively. Measurements did not differ significantly and showed a very good correlation (P > 0.05; R = 0.75/0.76/0.65).ASL kidney measurements combined with operator-independent semiautomatic segmentation revealed high correlation and low variance of cortical, medullary, and whole kidney perfusion.

Authors with CRIS profile

Matthias Hammon Institute of Radiology Rolf Matthias Janka Institute of Radiology Christian Siegl Chair of Visual Computing Hannes Seuß Professur für Plastische Chirurgie und Handchirurgie Roberto Grosso Chair of Visual Computing Roland Schmieder Professur für Innere Medizin (Nephrologie) Michael Uder Lehrstuhl für Diagnostische Radiologie

Involved external institutions

Universitätsklinikum Tübingen DE Germany (DE)

How to cite

APA:

Hammon, M., Janka, R.M., Siegl, C., Seuß, H., Grosso, R., Martirosian, P.,... Kistner, I. (2016). Reproducibility of Kidney Perfusion Measurements With Arterial Spin Labeling at 1.5 Tesla MRI Combined With Semiautomatic Segmentation for Differential Cortical and Medullary Assessment. Medicine, 95(11), e3083. https://dx.doi.org/10.1097/MD.0000000000003083

MLA:

Hammon, Matthias, et al. "Reproducibility of Kidney Perfusion Measurements With Arterial Spin Labeling at 1.5 Tesla MRI Combined With Semiautomatic Segmentation for Differential Cortical and Medullary Assessment." Medicine 95.11 (2016): e3083.

BibTeX: Download