Evaluation of angiogenesis of bioactive glass in the arteriovenous loop model

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autorinnen und Autoren: Arkudas A, Balzer A, Bührer G, Arnold I, Hoppe A, Detsch R, Newby P, Fey T, Greil P, Horch RE, Boccaccini AR, Kneser U
Zeitschrift: Tissue Engineering - Part C: Methods
Verlag: Mary Ann Liebert Inc.
Jahr der Veröffentlichung: 2013
Band: 19
Seitenbereich: 479-486
ISSN: 1937-3384


Abstract


In this study, the angiogenetic effect of sintered 45S5 Bioglass (R) was quantitatively assessed for the first time in the arteriovenous loop (AVL) model. An AVL was created by interposition of a venous graft from the contralateral side between the femoral artery and vein in the medial thigh of eight rats. The loop was placed in a Teflon isolation chamber and was embedded in a sintered 45S5 Bioglass (R) granula matrix filled with fibrin gel. Specimens were investigated 3 weeks postoperatively by means of microcomputed tomography, histological, and morphometrical techniques. All animals tolerated the operations well. At 3 weeks, both microcomputed tomography and histology demonstrated a dense network of newly formed vessels originating from the AVL. All constructs were filled with cell-rich, highly vascularized connective tissue around the vascular axis. Analysis of vessel diameter revealed constant small vessel diameters, indicating immature new vessel sprouts. This study shows for the first time axial vascularization of a sintered 45S5 Bioglass (R) granula matrix. After 3 weeks, the newly generated vascular network already interfused most parts of the scaffolds and showed signs of immaturity. The intrinsic type of vascularization allows transplantation of the entire construct using the AVL pedicle.



FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Arkudas, Andreas Prof. Dr.
Medizinische Fakultät
Arnold, Isabel
Lehrstuhl für funktionelle und klinische Anatomie
Boccaccini, Aldo R. Prof. Dr.-Ing.
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Bührer, Gregor
Medizinische Fakultät
Detsch, Rainer Dr.-Ing.
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Fey, Tobias Dr.
Lehrstuhl für Werkstoffwissenschaften (Glas und Keramik)
Greil, Peter Prof. Dr.
Lehrstuhl für Werkstoffwissenschaften (Glas und Keramik)
Hoppe, Alexander
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Horch, Raymund E. Prof. Dr.
Professur für Plastische Chirurgie und Handchirurgie


Einrichtungen weiterer Autorinnen und Autoren

Imperial College London / The Imperial College of Science, Technology and Medicine


Zitierweisen

APA:
Arkudas, A., Balzer, A., Bührer, G., Arnold, I., Hoppe, A., Detsch, R.,... Kneser, U. (2013). Evaluation of angiogenesis of bioactive glass in the arteriovenous loop model. Tissue Engineering - Part C: Methods, 19, 479-486. https://dx.doi.org/10.1089/ten.tec.2012.0572

MLA:
Arkudas, Andreas, et al. "Evaluation of angiogenesis of bioactive glass in the arteriovenous loop model." Tissue Engineering - Part C: Methods 19 (2013): 479-486.

BibTeX: 

Zuletzt aktualisiert 2019-18-07 um 07:31