Biosilicate®–gelatine bone scaffolds by the foam replica technique: development and characterization

Desimone D, Li W, Roether J, Schubert DW, Crovace M, Rodrigues A, Zanotto E, Boccaccini AR (2013)

Publication Language: English

Publication Type: Journal article, Review article

Publication year: 2013

Journal

Publisher: National Institute for Materials Science (NIMS) / Elsevier

Book Volume: 14

Article Number: 045008

DOI: 10.1088/1468-6996/14/4/045008

Abstract

The development of bioactive glass-ceramic materials has been a topic of great interest aiming at enhancing the mechanical strength of traditional bioactive scaffolds. In the present study, we test and demonstrate the use of Biosilicate^® glass-ceramic powder to fabricate bone scaffolds by the foam replica method. Scaffolds possessing the main requirements for use in bone tissue engineering (95% porosity, 200–500 μm pore size) were successfully produced. Gelatine coating was investigated as a simple approach to increase the mechanical competence of the scaffolds. The gelatine coating did not affect the interconnectivity of the pores and did not significantly affect the bioactivity of the Biosilicate^® scaffold. The gelatine coating significantly improved the compressive strength (i.e. 0.80 ± 0.05 MPa of coated versus 0.06 ± 0.01 MPa of uncoated scaffolds) of the Biosilicate^® scaffold. The combination of Biosilicate^® glass-ceramic and gelatine is attractive for producing novel scaffolds for bone tissue engineering.

Authors with CRIS profile

Involved external institutions

University of São Paulo / Universidade de São Paulo (USP) Brazil (BR) Imperial College London / The Imperial College of Science, Technology and Medicine United Kingdom (GB)

How to cite

APA:

Desimone, D., Li, W., Roether, J., Schubert, D.W., Crovace, M., Rodrigues, A.,... Boccaccini, A.R. (2013). Biosilicate®–gelatine bone scaffolds by the foam replica technique: development and characterization. Science and Technology of Advanced Materials, 14. https://doi.org/10.1088/1468-6996/14/4/045008

MLA:

Desimone, Deborah, et al. "Biosilicate®–gelatine bone scaffolds by the foam replica technique: development and characterization." Science and Technology of Advanced Materials 14 (2013).

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