Poly(Glycerol Sebacate) Films Modified by Thermal Proteins for Cardiac Tissue Engineering

Tallawi M, Rai R, Costa M, Roether J, Schubert DW, Boccaccini AR (2013)

Publication Language: English

Publication Type: Conference contribution, Abstract of lecture

Publication year: 2013

Book Volume: 791

Pages Range: 485-490

Event location: Innsbruck

DOI: 10.2316/P.2013.791-116

Abstract

Scaffolds for cardiac tissue engineering must be designed to achieve adequate degradation kinetics and mechanical properties. In this study, bulk modification of poly(glycerol sebacate) (PGS) with different concentrations of thermal proteins (TP) was investigated to tailor the degradation properties of PGS. TP are poly-amino acids formed by heating a mixture of amino acids with minimal proportions of glutamic or aspartic acid. The degradation study of TP-PGS was performed in vitro in phosphate buffered saline (PBS) solution over a 21 day period. Results showed that the degradation rate of PGS increased with increasing content of TP. After 21 days in PBS, degradation weight loss values of 9.40% ± 0.07, 7.3% ± 0.8 and 6.0% ± 0.4 were determined for PGS-TP-2g, PGS-TP-0.01g and PGS-control, respectively. The studies also showed that TP altered the mechanical properties and surface hydrophilicity of PGS.

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How to cite

APA:

Tallawi, M., Rai, R., Costa, M., Roether, J., Schubert, D.W., & Boccaccini, A.R. (2013, February). Poly(Glycerol Sebacate) Films Modified by Thermal Proteins for Cardiac Tissue Engineering. Paper presentation at Biomedical Engineering, Innsbruck, AT.

MLA:

Tallawi, Marwa, et al. "Poly(Glycerol Sebacate) Films Modified by Thermal Proteins for Cardiac Tissue Engineering." Presented at Biomedical Engineering, Innsbruck 2013.

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