Separation of racemic bicalutamide by an optimized combination of continuous chromatography and selective crystallization

Beitrag in einer Fachzeitschrift
(Originalarbeit)


Details zur Publikation

Autorinnen und Autoren: Kaemmerer H, Horvath Z, Lee JW, Kaspereit M, Arnell R, Hedberg M, Herschend B, Jones MJ, Larson K, Lorenz H, Seidel-Morgenstern A
Zeitschrift: Organic Process Research & Development
Verlag: American Chemical Society
Jahr der Veröffentlichung: 2012
Band: 16
Heftnummer: 2
Seitenbereich: 331-342
ISSN: 1083-6160
Sprache: Englisch


Abstract


A racemic mixture of bicalutamide, a drug substance used in the treatment of prostate cancer, was separated by simulated moving bed chromatography, with the objective of maximizing throughput at reduced outlet purity. The enriched extract stream was purified further by a crystallization process exploiting a shift in the eutectic composition. The optimal purity in between both process steps was identified. The separation scheme developed was validated on a scale of 600 g, and the results were compared to those of state-of-the art and discussed. The investigated scheme revealed a wide range of promising coupling conditions while showing superior productivities and enhanced process robustness. © 2011 American Chemical Society.



FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Kaspereit, Malte Prof. Dr.-Ing.
Professur für Thermische Verfahrenstechnik


Zitierweisen

APA:
Kaemmerer, H., Horvath, Z., Lee, J.W., Kaspereit, M., Arnell, R., Hedberg, M.,... Seidel-Morgenstern, A. (2012). Separation of racemic bicalutamide by an optimized combination of continuous chromatography and selective crystallization. Organic Process Research & Development, 16(2), 331-342. https://dx.doi.org/10.1021/op200136z

MLA:
Kaemmerer, Henning, et al. "Separation of racemic bicalutamide by an optimized combination of continuous chromatography and selective crystallization." Organic Process Research & Development 16.2 (2012): 331-342.

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