Separation of racemic bicalutamide by an optimized combination of continuous chromatography and selective crystallization

Kaemmerer H, Horvath Z, Lee JW, Kaspereit M, Arnell R, Hedberg M, Herschend B, Jones MJ, Larson K, Lorenz H, Seidel-Morgenstern A (2012)


Publication Language: English

Publication Status: Published

Publication Type: Journal article, Original article

Publication year: 2012

Journal

Publisher: American Chemical Society

Book Volume: 16

Pages Range: 331-342

Journal Issue: 2

DOI: 10.1021/op200136z

Abstract

A racemic mixture of bicalutamide, a drug substance used in the treatment of prostate cancer, was separated by simulated moving bed chromatography, with the objective of maximizing throughput at reduced outlet purity. The enriched extract stream was purified further by a crystallization process exploiting a shift in the eutectic composition. The optimal purity in between both process steps was identified. The separation scheme developed was validated on a scale of 600 g, and the results were compared to those of state-of-the art and discussed. The investigated scheme revealed a wide range of promising coupling conditions while showing superior productivities and enhanced process robustness. © 2011 American Chemical Society.

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How to cite

APA:

Kaemmerer, H., Horvath, Z., Lee, J.W., Kaspereit, M., Arnell, R., Hedberg, M.,... Seidel-Morgenstern, A. (2012). Separation of racemic bicalutamide by an optimized combination of continuous chromatography and selective crystallization. Organic Process Research & Development, 16(2), 331-342. https://dx.doi.org/10.1021/op200136z

MLA:

Kaemmerer, Henning, et al. "Separation of racemic bicalutamide by an optimized combination of continuous chromatography and selective crystallization." Organic Process Research & Development 16.2 (2012): 331-342.

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