Evaluation of competing process concepts for the production of pure enantiomers

Beitrag in einer Fachzeitschrift

Details zur Publikation

Autorinnen und Autoren: Kaspereit M, Swernath S, Kienle A
Zeitschrift: Organic Process Research & Development
Verlag: American Chemical Society
Jahr der Veröffentlichung: 2012
Band: 16
Heftnummer: 2
Seitenbereich: 353-363
ISSN: 1083-6160
Sprache: Englisch


Various promising concepts exist for improving the performance of productions of pure enantiomers. An efficient approach is developed for the systematic conceptual design of such processes. The proposed three-step procedure aids a fast selection of the optimal process configuration out of many possible candidates and leads to an optimally designed process. The approach is applied in a case study for an industrially relevant compound, considering different process concepts based on simulated moving bed chromatography, enantioselective crystallization, and racemization. It is demonstrated that mixed-integer nonlinear programming is capable of predicting simultaneously the optimal process configuration and optimal design parameters. © 2011 American Chemical Society.

FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Kaspereit, Malte Prof. Dr.-Ing.
Professur für Thermische Verfahrenstechnik


Kaspereit, M., Swernath, S., & Kienle, A. (2012). Evaluation of competing process concepts for the production of pure enantiomers. Organic Process Research & Development, 16(2), 353-363. https://dx.doi.org/10.1021/op200285v

Kaspereit, Malte, Subramanian Swernath, and Achim Kienle. "Evaluation of competing process concepts for the production of pure enantiomers." Organic Process Research & Development 16.2 (2012): 353-363.


Zuletzt aktualisiert 2018-18-10 um 21:50