Kaspereit M, Swernath S, Kienle A (2012)
Publication Language: English
Publication Status: Published
Publication Type: Journal article, Original article
Publication year: 2012
Publisher: American Chemical Society
Book Volume: 16
Pages Range: 353-363
Journal Issue: 2
DOI: 10.1021/op200285v
Various promising concepts exist for improving the performance of productions of pure enantiomers. An efficient approach is developed for the systematic conceptual design of such processes. The proposed three-step procedure aids a fast selection of the optimal process configuration out of many possible candidates and leads to an optimally designed process. The approach is applied in a case study for an industrially relevant compound, considering different process concepts based on simulated moving bed chromatography, enantioselective crystallization, and racemization. It is demonstrated that mixed-integer nonlinear programming is capable of predicting simultaneously the optimal process configuration and optimal design parameters. © 2011 American Chemical Society.
APA:
Kaspereit, M., Swernath, S., & Kienle, A. (2012). Evaluation of competing process concepts for the production of pure enantiomers. Organic Process Research & Development, 16(2), 353-363. https://dx.doi.org/10.1021/op200285v
MLA:
Kaspereit, Malte, Subramanian Swernath, and Achim Kienle. "Evaluation of competing process concepts for the production of pure enantiomers." Organic Process Research & Development 16.2 (2012): 353-363.
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