von Langermann J, Kaspereit M, Shakeri M, Lorenz H, Hedberg M, Jones MJ, Larson K, Herrschend B, Arnell R, Temmel E, Bäckvall JE, Kienle A, Seidel-Morgenstern A (2012)
Publication Language: English
Publication Status: Published
Publication Type: Journal article, Original article
Publication year: 2012
Publisher: American Chemical Society
Book Volume: 16
Pages Range: 343-352
Journal Issue: 2
DOI: 10.1021/op200268h
An integrated process for the chiral separation of the industrially relevant substance 2′,6′-pipecoloxylidide (PPX), an intermediate in the manufacture of a number of anesthetics, was developed. By combining three different techniques, chromatography, crystallization, and racemization, high productivity was achieved. All unit operations were executed using a common solvent system, full recycling, and a minimum of solvent exchanges or removals. The target molecule was obtained with an enantiopurity of >99.5 wt %. © 2012 American Chemical Society.
APA:
von Langermann, J., Kaspereit, M., Shakeri, M., Lorenz, H., Hedberg, M., Jones, M.J.,... Seidel-Morgenstern, A. (2012). Design of an integrated process of chromatography, crystallization and racemization for the resolution of 2′,6′-pipecoloxylidide (PPX). Organic Process Research & Development, 16(2), 343-352. https://dx.doi.org/10.1021/op200268h
MLA:
von Langermann, Jan, et al. "Design of an integrated process of chromatography, crystallization and racemization for the resolution of 2′,6′-pipecoloxylidide (PPX)." Organic Process Research & Development 16.2 (2012): 343-352.
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