Design of an integrated process of chromatography, crystallization and racemization for the resolution of 2′,6′-pipecoloxylidide (PPX)

Beitrag in einer Fachzeitschrift
(Originalarbeit)


Details zur Publikation

Autorinnen und Autoren: von Langermann J, Kaspereit M, Shakeri M, Lorenz H, Hedberg M, Jones MJ, Larson K, Herrschend B, Arnell R, Temmel E, Bäckvall JE, Kienle A, Seidel-Morgenstern A
Zeitschrift: Organic Process Research & Development
Verlag: American Chemical Society
Jahr der Veröffentlichung: 2012
Band: 16
Heftnummer: 2
Seitenbereich: 343-352
ISSN: 1083-6160
Sprache: Englisch


Abstract


An integrated process for the chiral separation of the industrially relevant substance 2′,6′-pipecoloxylidide (PPX), an intermediate in the manufacture of a number of anesthetics, was developed. By combining three different techniques, chromatography, crystallization, and racemization, high productivity was achieved. All unit operations were executed using a common solvent system, full recycling, and a minimum of solvent exchanges or removals. The target molecule was obtained with an enantiopurity of >99.5 wt %. © 2012 American Chemical Society.



FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Kaspereit, Malte Prof. Dr.-Ing.
Professur für Thermische Verfahrenstechnik


Zitierweisen

APA:
von Langermann, J., Kaspereit, M., Shakeri, M., Lorenz, H., Hedberg, M., Jones, M.J.,... Seidel-Morgenstern, A. (2012). Design of an integrated process of chromatography, crystallization and racemization for the resolution of 2′,6′-pipecoloxylidide (PPX). Organic Process Research & Development, 16(2), 343-352. https://dx.doi.org/10.1021/op200268h

MLA:
von Langermann, Jan, et al. "Design of an integrated process of chromatography, crystallization and racemization for the resolution of 2′,6′-pipecoloxylidide (PPX)." Organic Process Research & Development 16.2 (2012): 343-352.

BibTeX: 

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