Trehalose dimycolate interferes with FcγR-mediated phagosome maturation through Mincle, SHP-1 and FcγRIIB signalling.

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Details zur Publikation

Autor(en): Patin EC, Geffken AC, Willcocks S, Leschczyk C, Haas A, Nimmerjahn F, Lang R, Ward TH, Schaible UE
Zeitschrift: PLoS ONE
Jahr der Veröffentlichung: 2017
Band: 12
Heftnummer: 4
Seitenbereich: e0174973
ISSN: 1932-6203


Abstract


The causative agent of tuberculosis, Mycobacterium tuberculosis (M. tuberculosis), contains an abundant cell wall glycolipid and a crucial virulence factor, trehalose-6,6'-dimycolate (TDM). TDM causes delay of phagosome maturation and thus promotes survival of mycobacteria inside host macrophages by a not fully understood mechanism. TDM signals through the Monocyte-INducible C-type LEctin (Mincle), a recently identified pattern recognition receptor. Here we show that recruitment of Mincle by TDM coupled to immunoglobulin (Ig)G-opsonised beads during Fcγ receptor (FcγR)-mediated phagocytosis interferes with phagosome maturation. In addition, modulation of phagosome maturation by TDM requires SH2-domain-containing inositol polyphosphate 5' phosphatase (SHP-1) and the FcγRIIB, which strongly suggests inhibitory downstream signalling of Mincle during phagosome formation. Overall, our study reveals important mechanisms contributing to the virulence of TDM.



FAU-Autoren / FAU-Herausgeber

Lang, Roland Prof. Dr.
Professur für Angeborene Immunität und Pathogenerkennung
Nimmerjahn, Falk Prof. Dr.
Lehrstuhl für Genetik


Autor(en) der externen Einrichtung(en)
Forschungszentrum Borstel - Leibniz-Zentrum für Medizin und Biowissenschaften / Research Center Borstel - Leibniz-Center for Medicine and Biosciences
London School of Hygiene and Tropical Medicine
Rheinische Friedrich-Wilhelms-Universität Bonn


Zitierweisen

APA:
Patin, E.C., Geffken, A.C., Willcocks, S., Leschczyk, C., Haas, A., Nimmerjahn, F.,... Schaible, U.E. (2017). Trehalose dimycolate interferes with FcγR-mediated phagosome maturation through Mincle, SHP-1 and FcγRIIB signalling. PLoS ONE, 12(4), e0174973. https://dx.doi.org/10.1371/journal.pone.0174973

MLA:
Patin, Emmanuel C., et al. "Trehalose dimycolate interferes with FcγR-mediated phagosome maturation through Mincle, SHP-1 and FcγRIIB signalling." PLoS ONE 12.4 (2017): e0174973.

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Zuletzt aktualisiert 2018-10-08 um 19:09