Trehalose dimycolate interferes with FcγR-mediated phagosome maturation through Mincle, SHP-1 and FcγRIIB signalling.
Beitrag in einer Fachzeitschrift
Details zur Publikation
Autor(en): Patin EC, Geffken AC, Willcocks S, Leschczyk C, Haas A, Nimmerjahn F, Lang R, Ward TH, Schaible UE
Jahr der Veröffentlichung: 2017
Band: 12
Heftnummer: 4
Seitenbereich: e0174973
ISSN: 1932-6203
Abstract
The causative agent of tuberculosis, Mycobacterium tuberculosis (M. tuberculosis), contains an abundant cell wall glycolipid and a crucial virulence factor, trehalose-6,6'-dimycolate (TDM). TDM causes delay of phagosome maturation and thus promotes survival of mycobacteria inside host macrophages by a not fully understood mechanism. TDM signals through the Monocyte-INducible C-type LEctin (Mincle), a recently identified pattern recognition receptor. Here we show that recruitment of Mincle by TDM coupled to immunoglobulin (Ig)G-opsonised beads during Fcγ receptor (FcγR)-mediated phagocytosis interferes with phagosome maturation. In addition, modulation of phagosome maturation by TDM requires SH2-domain-containing inositol polyphosphate 5' phosphatase (SHP-1) and the FcγRIIB, which strongly suggests inhibitory downstream signalling of Mincle during phagosome formation. Overall, our study reveals important mechanisms contributing to the virulence of TDM.
FAU-Autoren / FAU-Herausgeber
| | | Professur für Angeborene Immunität und Pathogenerkennung |
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| Nimmerjahn, Falk Prof. Dr. |
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Autor(en) der externen Einrichtung(en)
→ Forschungszentrum Borstel - Leibniz-Zentrum für Medizin und Biowissenschaften / Research Center Borstel - Leibniz-Center for Medicine and Biosciences |
→ London School of Hygiene and Tropical Medicine |
→ Rheinische Friedrich-Wilhelms-Universität Bonn |
Zitierweisen
APA: | Patin, E.C., Geffken, A.C., Willcocks, S., Leschczyk, C., Haas, A., Nimmerjahn, F.,... Schaible, U.E. (2017). Trehalose dimycolate interferes with FcγR-mediated phagosome maturation through Mincle, SHP-1 and FcγRIIB signalling. PLoS ONE, 12(4), e0174973. https://dx.doi.org/10.1371/journal.pone.0174973 |
MLA: | Patin, Emmanuel C., et al. "Trehalose dimycolate interferes with FcγR-mediated phagosome maturation through Mincle, SHP-1 and FcγRIIB signalling." PLoS ONE 12.4 (2017): e0174973. |