Enz R (2002)
Publication Type: Journal article
Publication year: 2002
Book Volume: 514
Pages Range: 184-188
Journal Issue: 514
DOI: 10.1016/S0014-5793(02)02361-X
A yeast two-hybrid screen identified Filamin-A as a binding partner of the metabotropic glutamate receptor type 7b (mGluR7b) splice variant. In addition, Filamin-A interacted with mGluR4a, mGluR5a, mGluR5b, mGluR7a and mGluR8a. Domain mapping revealed that alternative splicing of mGluR4, mGluR7 and mGluR8 C-termini regulated the interaction. A conserved tyrosine within mGluR C-termini was identified to mediate the binding to Filamin-A. Protein interactions were verified in biochemical assays using recombinant and native proteins. Finally, co-expression of Filamin-A and mGluR7 splice variants was shown in brain regions. These findings suggest that Filamin-A may physically link metabotropic glutamate receptors to the actin cytoskeleton. © 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
APA:
Enz, R. (2002). The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7. FEBS letters, 514(514), 184-188. https://dx.doi.org/10.1016/S0014-5793(02)02361-X
MLA:
Enz, Ralf. "The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7." FEBS letters 514.514 (2002): 184-188.
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