Tumor location determines tissue-specific recruitment of tumor-associated macrophages and antibody-dependent immunotherapy response

Beitrag in einer Fachzeitschrift
(Originalarbeit)


Details zur Publikation

Autor(en): Lehmann B, Biburger M, Brückner C, Ipsen Escobedo A, Gordan S, Lehmann C, Vöhringer D, Winkler T, Schaft N, Dudziak D, Sirbu H, Weber G, Nimmerjahn F
Zeitschrift: Science immunology
Verlag: Science Immunology
Jahr der Veröffentlichung: 2017
Band: 2
Heftnummer: 7
ISSN: 2470-9468


Abstract


Despite recent advances in activating immune cells to target tumors, the presence of some immune cells, such as tumor-associated macrophages (TAMs) or tumor-associated neutrophils (TANs), may promote rather than inhibit tumor growth. However, it remains unclear how antibody-dependent tumor immunotherapies, such as cytotoxic or checkpoint control antibodies, affect different TAM or TAN populations, which abundantly express activating Fcγ receptors. In this study, we show that the tissue environment determines which cellular effector pathways are responsible for antibody-dependent tumor immunotherapy. Although TAMs derived from Ly6Chigh monocytes recruited by the CCL2-CCR2 axis were critical for tumor immunotherapy of skin tumors, the destruction of lung tumors was CCL2-independent and required the presence of colony-stimulating factor 2{\textendash}dependent tissue-resident macrophages. Our findings suggest that TAMs may have a dual role not only in promoting tumor growth in certain tissue environments on the one hand but also in contributing to tumor cell destruction during antibody-mediated immunotherapy on the other hand.



FAU-Autoren / FAU-Herausgeber

Biburger, Markus PD Dr.
Lehrstuhl für Genetik
Brückner, Christin
Lehrstuhl für Genetik
Dudziak, Diana Prof. Dr.
Professur für die Biologie Dendritischer Zellen
Gordan, Sina
Lehrstuhl für Genetik
Ipsen Escobedo, Andrea
Hautklinik
Lehmann, Christian Dr. rer. nat.
Hautklinik
Lehmann, Birgit Dr. rer. nat.
Lehrstuhl für Genetik
Nimmerjahn, Falk Prof. Dr.
Lehrstuhl für Genetik
Sirbu, Horia Prof. Dr.
Professur für Thoraxchirurgie
Vöhringer, David Prof. Dr.
Professur für Infektionsabwehr und Toleranz
Winkler, Thomas Prof. Dr.
Professur für Genetik


Zitierweisen

APA:
Lehmann, B., Biburger, M., Brückner, C., Ipsen Escobedo, A., Gordan, S., Lehmann, C.,... Nimmerjahn, F. (2017). Tumor location determines tissue-specific recruitment of tumor-associated macrophages and antibody-dependent immunotherapy response. Science immunology, 2(7). https://dx.doi.org/10.1126/sciimmunol.aah6413

MLA:
Lehmann, Birgit, et al. "Tumor location determines tissue-specific recruitment of tumor-associated macrophages and antibody-dependent immunotherapy response." Science immunology 2.7 (2017).

BibTeX: 

Zuletzt aktualisiert 2018-11-10 um 09:21