Wnt-5A/Ror2 regulate expression of XPAPC through an alternative noncanonical signaling pathway.

Beitrag in einer Fachzeitschrift
(Originalarbeit)


Details zur Publikation

Autorinnen und Autoren: Schambony A, Wedlich D
Zeitschrift: Developmental Cell
Verlag: Elsevier Inc.
Jahr der Veröffentlichung: 2007
Band: 12
Heftnummer: 5
Seitenbereich: 779-792
ISSN: 1534-5807


Abstract


XWnt-5A, a member of the nontransforming Wnt-5A class of Wnt ligands, is required for convergent extension movements in Xenopus embryos. XWnt-5A knockdown phenocopies paraxial protocadherin (XPAPC) loss of function: involuted mesodermal cells fail to align mediolaterally, which results in aberrant movements and a selective inhibition of constriction. XWnt-5A depletion was rescued by coinjection of XPAPC RNA, indicating that XWnt-5A acts upstream of XPAPC. XWnt-5A, but not XWnt-11, stimulates XPAPC expression independent of the canonical Wnt/beta-catenin pathway. We show that transcriptional regulation of XPAPC by XWnt-5A requires the receptor tyrosine kinase Ror2. XWnt-5A/Xror2 signal through PI3 kinase and cdc42 to activate the JNK signaling cascade with the transcription factors ATF2 and c-jun. The Wnt-5A/Ror2 pathway represents an alternative, distinct branch of noncanonical Wnt signaling that controls gene expression and is required in the regulation of convergent extension movements in Xenopus gastrulation.



FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Schambony, Alexandra Prof. Dr.
Lehrstuhl für Entwicklungsbiologie


Zitierweisen

APA:
Schambony, A., & Wedlich, D. (2007). Wnt-5A/Ror2 regulate expression of XPAPC through an alternative noncanonical signaling pathway. Developmental Cell, 12(5), 779-792. https://dx.doi.org/10.1016/j.devcel.2007.02.016

MLA:
Schambony, Alexandra, and Doris Wedlich. "Wnt-5A/Ror2 regulate expression of XPAPC through an alternative noncanonical signaling pathway." Developmental Cell 12.5 (2007): 779-792.

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