The LIM domain protein Wtip interacts with the receptor tyrosine kinase Ror2 and inhibits canonical Wnt signalling.

Beitrag in einer Fachzeitschrift
(Originalarbeit)


Details zur Publikation

Autorinnen und Autoren: Van Wijk NV, Witte F, Feike AC, Schambony A, Birchmeier W, Mundlos S, Stricker S
Zeitschrift: Biochemical and Biophysical Research Communications
Verlag: Elsevier Inc.
Jahr der Veröffentlichung: 2009
Band: 390
Heftnummer: 2
Seitenbereich: 211-216
ISSN: 0006-291X


Abstract


Wtip is a LIM domain protein of the Ajuba/Zyxin family involved in kidney and neural crest development; Ror2 is a receptor tyrosine kinase involved in the development of skeleton, heart, lung, genitalia and kidneys. Here we describe Wtip as an intracellular interaction partner of Ror2. Full-length Ror2 recruits Wtip to the cell membrane, a mutant involved in human disease fails to do so. Both genes and proteins show overlapping expression in the mouse embryo. We show that Wtip is able to inhibit canonical Wnt signalling in mammalian cells and in Xenopus embryos linking Wtip to a crucial developmental pathway.



FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Schambony, Alexandra Prof. Dr.
Lehrstuhl für Entwicklungsbiologie


Einrichtungen weiterer Autorinnen und Autoren

Max-Delbrück-Centrum für Molekulare Medizin (MDC) Berlin-Buch
Max-Planck-Institut für molekulare Genetik / Max Planck Institute for Molecular Genetics


Zitierweisen

APA:
Van Wijk, N.V., Witte, F., Feike, A.C., Schambony, A., Birchmeier, W., Mundlos, S., & Stricker, S. (2009). The LIM domain protein Wtip interacts with the receptor tyrosine kinase Ror2 and inhibits canonical Wnt signalling. Biochemical and Biophysical Research Communications, 390(2), 211-216. https://dx.doi.org/10.1016/j.bbrc.2009.09.086

MLA:
Van Wijk, Nicole Verhey, et al. "The LIM domain protein Wtip interacts with the receptor tyrosine kinase Ror2 and inhibits canonical Wnt signalling." Biochemical and Biophysical Research Communications 390.2 (2009): 211-216.

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Zuletzt aktualisiert 2018-10-08 um 15:53