Wnt5a/Ror2-induced upregulation of xPAPC requires xShcA.

Beitrag in einer Fachzeitschrift

Details zur Publikation

Autorinnen und Autoren: Feike AC, Rachor K, Gentzel M, Schambony A
Zeitschrift: Biochemical and Biophysical Research Communications
Verlag: Elsevier Inc.
Jahr der Veröffentlichung: 2010
Band: 400
Heftnummer: 4
Seitenbereich: 500-506
ISSN: 0006-291X


Ror receptor-tyrosine kinases act as Wnt-5a receptors in beta-catenin independent Wnt-signaling pathways. In Xenopus, expression of xPAPC is regulated by a Wnt-5a/Ror2 pathway, which resembles typical signaling cascades downstream of receptor-tyrosine kinases. Here, we have identified the phospho-tyrosine binding protein ShcA as an intracellular binding partner of Ror2. ShcA binds to a conserved motif in Ror2 via its SH2-domain. Wnt-5a induces clustering of Ror2 in the cell membrane and recruitment of ShcA to the Ror2 receptor complex. We further show that ShcA is co-expressed with Ror2 in developing Xenopus embryos and ShcA is required for Wnt-5a/Ror2 mediated upregulation of xPAPC, demonstrating the functional relevance of this interaction.

FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Schambony, Alexandra Prof. Dr.
Lehrstuhl für Entwicklungsbiologie

Einrichtungen weiterer Autorinnen und Autoren

Max-Planck-Institut für molekulare Zellbiologie und Genetik / Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG)


Feike, A.C., Rachor, K., Gentzel, M., & Schambony, A. (2010). Wnt5a/Ror2-induced upregulation of xPAPC requires xShcA. Biochemical and Biophysical Research Communications, 400(4), 500-506. https://dx.doi.org/10.1016/j.bbrc.2010.08.074

Feike, Ann Caroline, et al. "Wnt5a/Ror2-induced upregulation of xPAPC requires xShcA." Biochemical and Biophysical Research Communications 400.4 (2010): 500-506.


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