Biocompatibility of submicron Bioglass® powders obtained by a top-down approach

Dörfler A, Detsch R, Romeis S, Schmidt J, Eisermann C, Peukert W, Boccaccini AR (2014)

Publication Status: Published

Publication Type: Journal article, Original article

Publication year: 2014

Journal

Journal of Biomedical Materials Research Part B: Applied Biomaterials Wiley

Book Volume: 102

Pages Range: 952-961

Journal Issue: 5

DOI: 10.1002/jbm.b.33076

Abstract

In this study in vitro bioactivity and biocompatibility of two submicron 45S5 Bioglass powders obtained by top-down processing have been evaluated and are compared to the as-received powder. Both submicron powders exhibited flake-like morphologies with lateral extensions of only a few microns; the flake thickness accounted for a few tens of nanometers. Enhanced in vitro bioactivity was found for the comminuted powders upon immersion in simulated body fluid. In vitro biocompatibility was evaluated by incubation of MG-63 osteoblast-like cells with various amounts (0-200 μg/mL) of the glass powders. Neither LDH-activity nor mitochondrial activity (WST-8) tests indicated cell toxicity. Increased mitochondrial activity was found for the submicron powders: incubation with high amounts revealed up to a threefold increase of osteoblast activity (ALP-activity). An overgrowth of the formed mineralized phase with phenotypical MG-63 cells was found by staining only for the submicron glasses. A distance ring is formed for the as-received powder. Superior bioactivity markers are found for shorter process times, that is, lower mass specific surface areas. This is attributed to the formation of carbonates during the comminution process. © 2013 Wiley Periodicals, Inc.

Authors with CRIS profile

Anja Dörfler Lehrstuhl für Feststoff- und Grenzflächenverfahrenstechnik Rainer Detsch Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Stefan Romeis Lehrstuhl für Feststoff- und Grenzflächenverfahrenstechnik Jochen Schmidt Lehrstuhl für Feststoff- und Grenzflächenverfahrenstechnik Claudia Eisermann Lehrstuhl für Feststoff- und Grenzflächenverfahrenstechnik Wolfgang Peukert Lehrstuhl für Feststoff- und Grenzflächenverfahrenstechnik Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

How to cite

APA:

Dörfler, A., Detsch, R., Romeis, S., Schmidt, J., Eisermann, C., Peukert, W., & Boccaccini, A.R. (2014). Biocompatibility of submicron Bioglass® powders obtained by a top-down approach. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 102(5), 952-961. https://dx.doi.org/10.1002/jbm.b.33076

MLA:

Dörfler, Anja, et al. "Biocompatibility of submicron Bioglass® powders obtained by a top-down approach." Journal of Biomedical Materials Research Part B: Applied Biomaterials 102.5 (2014): 952-961.

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