The influence of additives on the nanoscopic dynamics of the phospholipid dimyristoylphosphatidylcholine

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autor(en): Busch S, Unruh T
Zeitschrift: Biochimica Et Biophysica Acta-Biomembranes
Verlag: ELSEVIER SCIENCE BV
Jahr der Veröffentlichung: 2011
Band: 1808
Heftnummer: 1
Seitenbereich: 199-208
ISSN: 0005-2736


Abstract


The influence of additives on the molecular dynamics of the phospholipid dimyristoylphosphatidylcholine (DMPC) in its fully hydrated liquid crystalline phase was studied. Quasielastic neutron scattering (QENS) was used to detect motions with dimensions of some Angstroms on two different time scales, namely 60 ps and 900 Ps. The effects of myristic acid, farnesol, cholesterol, and sodium glycocholate could consistently be explained on the basis of collective, flow-like motions of the phospholipid molecules. The influence of the additives on these motions was explained by packing effects, corresponding to the reduction of free volume. Cholesterol was found to decrease the mobility of DMPC seen on the 900 ps time scale with increasing cholesterol content. In contrast, all other studied additives have no significant effect on the mobility. (C) 2010 Elsevier B.V. All rights reserved.



FAU-Autoren / FAU-Herausgeber

Unruh, Tobias Prof. Dr.
Professur für Nanomaterialcharakterisierung (Streumethoden)


Autor(en) der externen Einrichtung(en)
Technische Universität München (TUM)


Zitierweisen

APA:
Busch, S., & Unruh, T. (2011). The influence of additives on the nanoscopic dynamics of the phospholipid dimyristoylphosphatidylcholine. Biochimica Et Biophysica Acta-Biomembranes, 1808(1), 199-208. https://dx.doi.org/10.1016/j.bbamem.2010.10.012

MLA:
Busch, Sebastian, and Tobias Unruh. "The influence of additives on the nanoscopic dynamics of the phospholipid dimyristoylphosphatidylcholine." Biochimica Et Biophysica Acta-Biomembranes 1808.1 (2011): 199-208.

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Zuletzt aktualisiert 2018-06-08 um 20:23