Physicochemical characterization of silicon-containing glycolipids by DSC, FT-Raman spectroscopy and X-ray diffraction

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autorinnen und Autoren: Uhr M, Wartewig S, Unruh T, Richter H
Zeitschrift: Chemistry and Physics of Lipids
Verlag: ELSEVIER SCI IRELAND LTD
Jahr der Veröffentlichung: 2003
Band: 124
Heftnummer: 1
Seitenbereich: 1-13
ISSN: 0009-3084


Abstract


Derivatives of dimethylalkylchlorosilanes are novel substances which may be used in formulations for drug targeting. In order to design their properties it is essential to perform physicochemical characterization. For this purpose, a combination of differential scanning calorimetry (DSC), FT-Raman spectroscopy and X-ray diffraction is well suited. For the starting material dimethyloctadecylchlorosilane (DMOC), the assignment of Raman bands is discussed. The influence of sugar-containing head groups on the structures of the hydrocarbon chains of 1-O-(dimethyldodecylsilyl)-[2,3,4,6-tetra-O-acetyl-beta-D-glucopyranoside] and 1-O-(dimethyloctadecylsilyl)-[2,3,4,6-tetra-O-acetyl-beta-D-glucopyranoside] was investigated using the band position of the symmetric methylene mode. The temperature dependence of conformationally sensitive bands in the CH2-stretching region (2800-2900cm(-1)), C-C-stretching region (1000-1150cm(-1)) and CH3-rocking region (830-900cm(-1)) was studied to characterize the state of order of the alkyl chains. Using X-ray diffraction, the repeating distances of layered structures was determined. The phase transitions occurring were found to be completely reversible. The subcell of DMOC shows an orthorhombic perpendicular packing structure in the crystalline state. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.



FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Unruh, Tobias Prof. Dr.
Professur für Nanomaterialcharakterisierung (Streumethoden)


Einrichtungen weiterer Autorinnen und Autoren

Martin-Luther-Universität Halle-Wittenberg (MLU)


Zitierweisen

APA:
Uhr, M., Wartewig, S., Unruh, T., & Richter, H. (2003). Physicochemical characterization of silicon-containing glycolipids by DSC, FT-Raman spectroscopy and X-ray diffraction. Chemistry and Physics of Lipids, 124(1), 1-13. https://dx.doi.org/10.1016/S0009-3084(03)00021-5

MLA:
Uhr, Michael, et al. "Physicochemical characterization of silicon-containing glycolipids by DSC, FT-Raman spectroscopy and X-ray diffraction." Chemistry and Physics of Lipids 124.1 (2003): 1-13.

BibTeX: 

Zuletzt aktualisiert 2018-06-08 um 20:23