Characterization of lipid nanoparticles by differential scanning calorimetry, X-ray and neutron scattering

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autor(en): Bunjes H, Unruh T
Zeitschrift: Advanced Drug Delivery Reviews
Verlag: ELSEVIER SCIENCE BV
Jahr der Veröffentlichung: 2007
Band: 59
Heftnummer: 6
Seitenbereich: 379-402
ISSN: 0169-409X
eISSN: 1872-8294


Abstract


Differential scanning calorimetry and X-ray diffraction play a prominent role in the characterization of lipid nanoparticle (LNP) dispersions. This review shortly outlines the measurement principles of these two techniques and summarizes their applications in the field of nanodispersions of solid lipids. These methods are particularly useful for the characterization of the matrix state, polymorphism and phase behavior of the nanoparticles which may be affected by, for example, the small particle size and the composition of the dispersions. The basics of small angle Xray and neutron scattering which are also very promising methods for the characterization of LNPs are explained in some more detail. Examples for their use in the area of solid LNPs regarding the evaluation of particle size effects and the formation of superstructures in the nanoparticle dispersions are given. Some technical questions concerning the use of the different characterization techniques in the field of LNP research are also addressed. (c) 2007 Elsevier BY. All rights reserved.



FAU-Autoren / FAU-Herausgeber

Unruh, Tobias Prof. Dr.
Professur für Nanomaterialcharakterisierung (Streumethoden)


Autor(en) der externen Einrichtung(en)
Friedrich-Schiller-Universität Jena


Zitierweisen

APA:
Bunjes, H., & Unruh, T. (2007). Characterization of lipid nanoparticles by differential scanning calorimetry, X-ray and neutron scattering. Advanced Drug Delivery Reviews, 59(6), 379-402. https://dx.doi.org/10.1016/j.addr.2007.04.013

MLA:
Bunjes, Heike, and Tobias Unruh. "Characterization of lipid nanoparticles by differential scanning calorimetry, X-ray and neutron scattering." Advanced Drug Delivery Reviews 59.6 (2007): 379-402.

BibTeX: 

Zuletzt aktualisiert 2019-08-03 um 14:02