FcγR dependent mechanisms of cytotoxic, agonistic, and neutralizing antibody activities.

Nimmerjahn F, Gordan S, Lux A (2015)


Publication Status: Published

Publication Type: Journal article, Review article

Publication year: 2015

Journal

Book Volume: 36

Pages Range: 325-36

Journal Issue: 6

DOI: 10.1016/j.it.2015.04.005

Abstract

Given the widespread use of antibodies of the immunoglobulin G (IgG) class as cytotoxic, immunomodulatory, and neutralizing agents in the therapy of malignant, infectious, and autoimmune diseases, understanding the molecular and cellular mechanisms responsible for their therapeutic activity is of major importance. While Fcγ receptors (FcγR) have well-appreciated roles as effectors of cytotoxic IgG activity, it has only recently become clear that the functionality of immunomodulatory and neutralizing IgG preparations also depends on cellular FcγRs. Here, we review current models of IgG activity in infectious and inflammatory settings, and examine the importance of cell type-specific expression of FcγRs in determining functional outcome. We discuss how this knowledge may be used to improve the activity of therapeutic antibody preparations and outline important areas of focus for future research.

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How to cite

APA:

Nimmerjahn, F., Gordan, S., & Lux, A. (2015). FcγR dependent mechanisms of cytotoxic, agonistic, and neutralizing antibody activities. Trends in immunology, 36(6), 325-36. https://dx.doi.org/10.1016/j.it.2015.04.005

MLA:

Nimmerjahn, Falk, Sina Gordan, and Anja Lux. "FcγR dependent mechanisms of cytotoxic, agonistic, and neutralizing antibody activities." Trends in immunology 36.6 (2015): 325-36.

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