The Drosophila Hand gene is required for remodeling of the developing adult heart and midgut during metamorphosis

Beitrag in einer Fachzeitschrift
(Originalarbeit)


Details zur Publikation

Autorinnen und Autoren: Lo P, Zaffran S, Senatore S, Frasch M
Zeitschrift: Developmental Biology
Verlag: ACADEMIC PRESS INC ELSEVIER SCIENCE
Jahr der Veröffentlichung: 2007
Band: 311
Heftnummer: 2
Seitenbereich: 287-296
ISSN: 0012-1606


Abstract


The Hand proteins of the bHLH family of transcriptional factors play critical roles in vertebrate cardiogenesis. In Drosophila, the single orthologous Hand gene is expressed in the developing embryonic dorsal vessel (heart), lymph glands, circular visceral musculature, and a subset of CNS cells. We demonstrate that the absence of Hand activity causes semilethality during the early larval instars. The dorsal vessel and midgut musculature are unaffected in null mutant embryos, but in a large fraction the lymph glands are missing. However, homozygous adult flies lacking Hand possess morphologically abnormal dorsal vessels characterized by a disorganized myofibrillar structure, reduced systolic and diastolic diameter, and abnormal heartbeat contractions, and suffer from premature lethality. In addition, their midguts are highly deformed; in the most severe cases, there is midgut blockage and a massive excess of ectopic peritrophic membrane tubules exiting a rupture in an anterior midgut bulge. Nevertheless, the visceral musculature appears to be relatively normal. Based on these phenotypes, we conclude that the expression of the Drosophila Hand gene in the dorsal vessel and circular visceral muscles is mainly required during pupal stages, when Hand participates in the proper hormone-dependent remodeling of the larval aorta into the adult heart and in the normal morphogenesis of the adult midgut endoderm during metamorphosis. (c) 2007 Elsevier Inc. All rights reserved.



FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Frasch, Manfred Prof. Dr.
Lehrstuhl für Entwicklungsbiologie


Zitierweisen

APA:
Lo, P., Zaffran, S., Senatore, S., & Frasch, M. (2007). The Drosophila Hand gene is required for remodeling of the developing adult heart and midgut during metamorphosis. Developmental Biology, 311(2), 287-296. https://dx.doi.org/10.1016/j.ydbio.2007.08.024

MLA:
Lo, Patrick, et al. "The Drosophila Hand gene is required for remodeling of the developing adult heart and midgut during metamorphosis." Developmental Biology 311.2 (2007): 287-296.

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