Mechano-regulation of the beating heart at the cellular level - Mechanosensitive channels in normal and diseased heart

Friedrich O, Wagner S, Battle A, Schürmann S, Martinac B (2012)

Publication Language: English

Publication Status: Published

Publication Type: Journal article, Review article

Publication year: 2012

Journal

Progress in Biophysics & Molecular Biology Elsevier

Publisher: Elsevier

Book Volume: 110

Pages Range: 226-238

Journal Issue: 2-3

DOI: 10.1016/j.pbiomolbio.2012.08.009

Abstract

The heart as a contractile hollow organ finely tunes mechanical parameters such as stroke volume, stroke pressure and cardiac output according to filling volumes, filling pressures via intrinsic and neuronal routes. At the cellular level, cardiomyocytes in beating hearts are exposed to large mechanical stress during successive heart beats. Although the mechanisms of excitation-contraction coupling are well established in mammalian heart cells, the putative contribution of mechanosensitive channels to Ca homeostasis, Ca signaling and force generation has been primarily investigated in relation to heart disease states. For instance, transient receptor potential channels (TRPs) are up-regulated in animal models of congestive heart failure or hypertension models and seem to play a vital role in pathological Ca overload to cardiomyocytes, thus aggravating the pathology of disease at the cellular level. Apart from that, the contribution of mechanosensitive channels (MsC) in the normal beating heart to the downstream force activation cascade has not been addressed. We present an overview of the current literature and concepts of mechanosensitive channel involvement in failing hearts and cardiomyopathies and novel data showing a likely contribution of Ca influx via mechanosensitive channels in beating normal cardiomyocytes during systolic shortening. © 2012 Elsevier Ltd.

Authors with CRIS profile

Oliver Friedrich Lehrstuhl für Medizinische Biotechnologie Sören Wagner Department of Anaesthesiology Sebastian Schürmann Lehrstuhl für Medizinische Biotechnologie

Related research project(s)

PPP Australia - Mechanotransduction and Ca2+-regulation in contracting cardiomyocytes Jan. 1, 2012 - Dec. 31, 2013 Role of mechanosensitive chanels in Ca2+ signaling in contracting cardiomyocytes Jan. 1, 2010 - Dec. 31, 2010

Involved external institutions

Griffith University AU Australia (AU) Victor Chang Cardiac Research Institute AU Australia (AU)

How to cite

APA:

Friedrich, O., Wagner, S., Battle, A., Schürmann, S., & Martinac, B. (2012). Mechano-regulation of the beating heart at the cellular level - Mechanosensitive channels in normal and diseased heart. Progress in Biophysics & Molecular Biology, 110(2-3), 226-238. https://doi.org/10.1016/j.pbiomolbio.2012.08.009

MLA:

Friedrich, Oliver, et al. "Mechano-regulation of the beating heart at the cellular level - Mechanosensitive channels in normal and diseased heart." Progress in Biophysics & Molecular Biology 110.2-3 (2012): 226-238.

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