Activation of membrane-located Ca2+ channels by hop beta acids and their tricyclic transformation products

Schulz C, Fritz N, Sommer T, Krofta K, Friedland K, Pischetsrieder M (2018)

Publication Status: Published

Publication Type: Journal article

Publication year: 2018

Journal

Food Chemistry Elsevier

Publisher: ELSEVIER SCI LTD

Book Volume: 252

Pages Range: 215-227

DOI: 10.1016/j.foodchem.2018.01.073

Abstract

Beta-bitter acids of hops (lupulones) revealed sedative and antidepressant-like effects in animal studies. Transformation of beta-acids during beer brewing leads to the formation of tricyclic transformation products, which have a close structural analogy to hyperforin. The latter compound is responsible for the antidepressant activity of St. John's wort by activation of TRPC6 cation channels in neuronal-like cells leading to Ca2+ influx. In this study, nortricyclolupones, dehydrotricyclolupones, and tricyclolupones were isolated from a wort-boiling model and their structures were elucidated by UHPLC-DAD, UHPLC-ESI--MS/MS and 1D/2D-NMR spectroscopy. Beta-bitter acids and their transformation products induced Ca2+ influx in PC12 cells to the same extent as hyperforin. Application of a Ca2+-free environment abolished the Ca2+ elevation, indicating that the increase is mediated by influx across the plasma membrane. Thus, activation of neuronal-like Ca2+-channels by lupulones and tricyclolupones represent a novel mechanism contributing to the antidepressant activity of hops.

Authors with CRIS profile

Carolin Schulz Lehrstuhl für Lebensmittelchemie (Henriette-Schmidt-Burkhardt Lehrstuhl) Nikolas Fritz Professur für Molekulare und Klinische Pharmazie Thomas Sommer Lehrstuhl für Lebensmittelchemie (Henriette-Schmidt-Burkhardt Lehrstuhl) Kristina Friedland Professur für Molekulare und Klinische Pharmazie Monika Pischetsrieder Lehrstuhl für Lebensmittelchemie (Henriette-Schmidt-Burkhardt Lehrstuhl)

Involved external institutions

Hop Research Institute Co., LTD CZ Czech Republic (CZ)

How to cite

APA:

Schulz, C., Fritz, N., Sommer, T., Krofta, K., Friedland, K., & Pischetsrieder, M. (2018). Activation of membrane-located Ca2+ channels by hop beta acids and their tricyclic transformation products. Food Chemistry, 252, 215-227. https://dx.doi.org/10.1016/j.foodchem.2018.01.073

MLA:

Schulz, Carolin, et al. "Activation of membrane-located Ca2+ channels by hop beta acids and their tricyclic transformation products." Food Chemistry 252 (2018): 215-227.

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