Cyclometalated platinum(II) complexes containing monodentate phosphines: antiproliferative study
Samouei H, Rashidi M, Heinemann FW (2014)
Publication Status: Published
Publication Type: Journal article
Publication year: 2014
Journal
Publisher: SPRINGER
Book Volume: 11
Pages Range: 1207-1216
Journal Issue: 4
DOI: 10.1007/s13738-013-0389-z
Abstract
Reaction of cyclometalated platinum(II) precursor [Pt(C boolean AND N)Cl(dmso)], 1, C boolean AND N = N(1), C(2')-chelated deprotonated 2-phenylpyridine and dmso = dimethylsulfoxide, with 1 equivalent of triphenyl phosphine, PPh3, or 1,3,5-triaza-7-phosphaadamantane, PTA, gave the complex [Pt(C boolean AND N)Cl(PPh3)], 2, or [Pt(C boolean AND N)Cl(PTA)], 3, respectively. On the basis of careful multinuclear NMR spectroscopy, supported by a number of 2D NMR experiments, structures of the complexes 2 and 3 in solution were determined to be neutral four coordinate. The X-ray crystallography indicated that the solid-state structure of complex 3 comprised a common square-planar geometry around platinum(II). Cytotoxicity of the complexes 2 and 3 was studied in three human cancer cell lines derived from ovarian carcinoma (CH1), lung carcinoma (A549), and colon carcinoma (SW480).
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Iran, Islamic Republic of (IR)How to cite
APA:
Samouei, H., Rashidi, M., & Heinemann, F.W. (2014). Cyclometalated platinum(II) complexes containing monodentate phosphines: antiproliferative study. Journal of the Iranian Chemical Society, 11(4), 1207-1216. https://doi.org/10.1007/s13738-013-0389-z
MLA:
Samouei, Hamidreza, Mehdi Rashidi, and Frank Wilhelm Heinemann. "Cyclometalated platinum(II) complexes containing monodentate phosphines: antiproliferative study." Journal of the Iranian Chemical Society 11.4 (2014): 1207-1216.
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