2,4-diamino-9H-pyrimido[4,5-b]indol-5-ols: Synthesis, in vitro cytotoxic activity, and QSAR investigations

Beitrag in einer Fachzeitschrift
(Originalarbeit)


Details zur Publikation

Autorinnen und Autoren: Dotzauer B, Grunert R, Bednarski PJ, Lanig H, Landwehr J, Troschütz R
Zeitschrift: Bioorganic & Medicinal Chemistry
Verlag: PERGAMON-ELSEVIER SCIENCE LTD
Jahr der Veröffentlichung: 2006
Band: 14
Heftnummer: 21
Seitenbereich: 7282-7292
ISSN: 0968-0896


Abstract


A series of novel 2,4-diaminopyrimido[4,5-b]indol-6-ols has been synthesized and the in vitro cytotoxic activities were evaluated against four human cancer cell lines originating from solid tumors. An increase in activity was observed when a heteroaromatic ring was annulated on side g of the pyrimido[4,5-b]indole system to give compounds with activities comparable to ellipticine and cisplatin. To understand the experimental cytotoxic activities, QSAR investigations were performed, which showed a very good linearity between the experimental and predicted IC50. (c) 2006 Elsevier Ltd. All rights reserved.



Zitierweisen

APA:
Dotzauer, B., Grunert, R., Bednarski, P.J., Lanig, H., Landwehr, J., & Troschütz, R. (2006). 2,4-diamino-9H-pyrimido[4,5-b]indol-5-ols: Synthesis, in vitro cytotoxic activity, and QSAR investigations. Bioorganic & Medicinal Chemistry, 14(21), 7282-7292. https://dx.doi.org/10.1016/j.bmc.2006.06.051

MLA:
Dotzauer, Bernd, et al. "2,4-diamino-9H-pyrimido[4,5-b]indol-5-ols: Synthesis, in vitro cytotoxic activity, and QSAR investigations." Bioorganic & Medicinal Chemistry 14.21 (2006): 7282-7292.

BibTeX: 

Zuletzt aktualisiert 2018-11-08 um 02:29