Dynamics and control of coupled continuous chromatography and crystallization processes for the production of pure enantiomers

Beitrag in einer Fachzeitschrift
(Originalarbeit)


Details zur Publikation

Autorinnen und Autoren: Swernath S, Kaspereit M, Kienle A
Zeitschrift: Chemical Engineering & Technology
Verlag: Wiley-VCH Verlag
Jahr der Veröffentlichung: 2013
Band: 36
Heftnummer: 8
Seitenbereich: 1417-1429
ISSN: 0930-7516
Sprache: Englisch


Abstract


The combination of continuous chromatographic processes and subsequent crystallization with a recycle of the mother liquor can improve significantly the efficiency of separation processes for the production of enantiomers if compared to the stand-alone chromatographic process. For the first time, dynamic operability and plantwide control of such a process combination is investigated. In the first step, the effect of disturbances on the open loop dynamics is evaluated. In a second step, a simple plantwide control strategy is proposed in order to ensure a robust process operation. It is demonstrated that the direct control of the simulated moving bed (SMB) unit is not required to stabilize the process combination while maintaining the desired product specifications. Instead, this can be achieved easily by controlling the amount of solvent removed or added to the system. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.



FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Kaspereit, Malte Prof. Dr.-Ing.
Professur für Thermische Verfahrenstechnik


Zitierweisen

APA:
Swernath, S., Kaspereit, M., & Kienle, A. (2013). Dynamics and control of coupled continuous chromatography and crystallization processes for the production of pure enantiomers. Chemical Engineering & Technology, 36(8), 1417-1429. https://dx.doi.org/10.1002/ceat.201200279

MLA:
Swernath, Subramanian, Malte Kaspereit, and Achim Kienle. "Dynamics and control of coupled continuous chromatography and crystallization processes for the production of pure enantiomers." Chemical Engineering & Technology 36.8 (2013): 1417-1429.

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Zuletzt aktualisiert 2019-08-04 um 14:51