The impact of microgravity-based proteomics research

Beitrag in einer Fachzeitschrift
(Review-Artikel)


Details zur Publikation

Autor(en): Grimm D, Pietsch J, Wehland M, Richter P, Strauch S, Lebert M, Magnusson NE, Wise P, Bauer J
Zeitschrift: Expert Review of Proteomics
Jahr der Veröffentlichung: 2014
Band: 11
Heftnummer: 4
Seitenbereich: 465-476
ISSN: 1744-8387


Abstract


Proteomics is performed in microgravity research in order to determine protein alterations occurring qualitatively and quantitatively, when single cells or whole organisms are exposed to real or simulated microgravity. To this purpose, antibody-dependent (Western blotting, flow cytometry, Luminex technology) and antibody-independent (mass spectrometry, gene array) techniques are applied. The anticipated findings will help to understand microgravity-specific behavior, which has been observed in bacteria, as well as in plant, animal and human cells. To date, the analyses revealed that cell cultures are more sensitive to microgravity than cells embedded in organisms and that proteins changing under microgravity are highly interactive. Furthermore, one has to distinguish between primary gravity-induced and subsequent interaction-dependent changes of proteins, as well as between direct microgravity-related effects and indirect stress responses. Progress in this field will impact on tissue engineering and medicine and will uncover possibilities of counteracting alterations of protein expression at lowered gravity. © 2014 Informa UK, Ltd.



FAU-Autoren / FAU-Herausgeber

Lebert, Michael PD Dr.
Lehrstuhl für Zellbiologie
Richter, Peter Dr.
Lehrstuhl für Zellbiologie
Strauch, Sebastian Dr.
Lehrstuhl für Zellbiologie


Autor(en) der externen Einrichtung(en)
Aarhus University
Max-Planck-Institut für Biochemie / Max Planck Institute of Biochemistry
Otto-von-Guericke-Universität Magdeburg
University of Southern California (USC)


Zitierweisen

APA:
Grimm, D., Pietsch, J., Wehland, M., Richter, P., Strauch, S., Lebert, M.,... Bauer, J. (2014). The impact of microgravity-based proteomics research. Expert Review of Proteomics, 11(4), 465-476. https://dx.doi.org/10.1586/14789450.2014.926221

MLA:
Grimm, Daniela, et al. "The impact of microgravity-based proteomics research." Expert Review of Proteomics 11.4 (2014): 465-476.

BibTeX: 

Zuletzt aktualisiert 2018-29-11 um 13:50