The impact of microgravity-based proteomics research

Journal article
(Review article)

Publication Details

Author(s): Grimm D, Pietsch J, Wehland M, Richter P, Strauch S, Lebert M, Magnusson NE, Wise P, Bauer J
Journal: Expert Review of Proteomics
Publication year: 2014
Volume: 11
Journal issue: 4
Pages range: 465-476
ISSN: 1744-8387


Proteomics is performed in microgravity research in order to determine protein alterations occurring qualitatively and quantitatively, when single cells or whole organisms are exposed to real or simulated microgravity. To this purpose, antibody-dependent (Western blotting, flow cytometry, Luminex technology) and antibody-independent (mass spectrometry, gene array) techniques are applied. The anticipated findings will help to understand microgravity-specific behavior, which has been observed in bacteria, as well as in plant, animal and human cells. To date, the analyses revealed that cell cultures are more sensitive to microgravity than cells embedded in organisms and that proteins changing under microgravity are highly interactive. Furthermore, one has to distinguish between primary gravity-induced and subsequent interaction-dependent changes of proteins, as well as between direct microgravity-related effects and indirect stress responses. Progress in this field will impact on tissue engineering and medicine and will uncover possibilities of counteracting alterations of protein expression at lowered gravity. © 2014 Informa UK, Ltd.

FAU Authors / FAU Editors

Lebert, Michael PD Dr.
Lehrstuhl für Zellbiologie
Richter, Peter Dr.
Lehrstuhl für Zellbiologie
Strauch, Sebastian Dr.
Lehrstuhl für Zellbiologie

External institutions with authors

Aarhus University
Max-Planck-Institut für Biochemie / Max Planck Institute of Biochemistry
Otto-von-Guericke-Universität Magdeburg
University of Southern California (USC)

How to cite

Grimm, D., Pietsch, J., Wehland, M., Richter, P., Strauch, S., Lebert, M.,... Bauer, J. (2014). The impact of microgravity-based proteomics research. Expert Review of Proteomics, 11(4), 465-476.

Grimm, Daniela, et al. "The impact of microgravity-based proteomics research." Expert Review of Proteomics 11.4 (2014): 465-476.


Last updated on 2018-29-11 at 13:50