CREB signalling regulates early survival, neuronal gene expression and morphological development in adult subventricular zone neurogenesis

Herold S, Jagasia R, Merz K, Wassmer K, Lie DC (2011)

Publication Type: Journal article

Publication year: 2011

Journal

Molecular and Cellular Neuroscience Elsevier

Publisher: Elsevier

Book Volume: 46

Pages Range: 79-88

Journal Issue: 1

DOI: 10.1016/j.mcn.2010.08.008

Abstract

Neural stem cells in the subventricular zone (SVZ) of the lateral ventricles give rise to new interneurons of the olfactory bulb (OB) throughout life. SVZ/OB neurogenesis is influenced by olfactory network activity, which modulates the survival of new neurons during their integration into the OB network. Previous work suggested that such activity-dependent survival is regulated via the CREB signalling pathway. Curiously, CREB signalling is already active during the early developmental stages of adult SVZ/OB neurogenesis. To investigate the role of cell autonomous CREB signalling during early stages of adult SVZ/OB neurogenesis, we ablated CREB-pathway activity in the SVZ/OB neurogenic lineage using a retroviral strategy. Surprisingly, loss of CREB signalling resulted in increased cell death and loss of expression of the neurogenic transcription factor Pax 6, and of a subset of neuronal proteins in migrating neurons of the RMS. Moreover, post-migratory neurons in the OB displayed impaired dendritic development. These results demonstrate an essential role for CREB signalling in maturation of newborn neurons in the OB and uncover a novel role for CREB signalling in the survival and maintenance of neuronal gene expression during the early stages of SVZ/OB neurogenesis.

Authors with CRIS profile

Dieter Chichung Lie Institut für Biochemie

Involved external institutions

Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich DE Germany (DE)

How to cite

APA:

Herold, S., Jagasia, R., Merz, K., Wassmer, K., & Lie, D.C. (2011). CREB signalling regulates early survival, neuronal gene expression and morphological development in adult subventricular zone neurogenesis. Molecular and Cellular Neuroscience, 46(1), 79-88. https://doi.org/10.1016/j.mcn.2010.08.008

MLA:

Herold, S., et al. "CREB signalling regulates early survival, neuronal gene expression and morphological development in adult subventricular zone neurogenesis." Molecular and Cellular Neuroscience 46.1 (2011): 79-88.

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