Gordan S, Biburger M, Nimmerjahn F (2015)
Publication Status: Published
Publication Type: Journal article, Review article
Publication year: 2015
Book Volume: 268
Pages Range: 52-65
Journal Issue: 1
DOI: 10.1111/imr.12347
The mononuclear phagocytic system consists of a great variety of cell subsets localized throughout the body in immunological and non-immunological tissues. While one of their prime tasks is to detect, phagocytose, and kill intruding microorganisms, they are also involved in maintaining tissue homeostasis and immune tolerance toward self through removal of dying cells. Furthermore, monocytes and macrophages have been recognized to play a critical role for mediating immunoglobulin G (IgG)-dependent effector functions, including target cell depletion, tissue inflammation, and immunomodulation. For this, monocyte and macrophage populations are equipped with a complex set of Fc-receptors, enabling them to directly interact with pro- or anti-inflammatory IgG preparations. In this review, we will summarize the most recent findings, supporting a central role of monocytes and macrophages for pro- and anti-inflammatory IgG activity. © 2015 John Wiley & Sons A/S. Published by John Wiley
APA:
Gordan, S., Biburger, M., & Nimmerjahn, F. (2015). bIgG time for large eaters: Monocytes and macrophages as effector and target cells of antibody-mediated immune activation and repression. Immunological Reviews, 268(1), 52-65. https://dx.doi.org/10.1111/imr.12347
MLA:
Gordan, Sina, Markus Biburger, and Falk Nimmerjahn. "bIgG time for large eaters: Monocytes and macrophages as effector and target cells of antibody-mediated immune activation and repression." Immunological Reviews 268.1 (2015): 52-65.
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